A Neonate with Acquired Factor VII Deficiency Successfully Managed with Immunomodulatory Therapy.
| Autor: | Alqarni NS; Hematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.; Oncology Department, King Faisal Special Hospital and Research Center, Jeddah, Saudi Arabia., Algiraigri AH; Hematology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia.; Oncology Department, King Faisal Special Hospital and Research Center, Jeddah, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | International journal of pediatrics & adolescent medicine [Int J Pediatr Adolesc Med] 2021 Sep; Vol. 8 (3), pp. 195-197. Date of Electronic Publication: 2020 Dec 09. |
| DOI: | 10.1016/j.ijpam.2020.12.002 |
| Abstrakt: | Acquired factor VII deficiency secondary to circulating inhibitors is rare in children but is a potentially life-threatening condition. Such a disease is challenging to diagnose and often difficult to manage. Here, we report on a newborn that presented with a catastrophic intracranial hemorrhage who failed to respond to conventional supportive measures including multiple doses of fresh frozen plasma and factor VII replacement; however, he had a complete correction of prothrombin time 8 h after immunomodulatory therapies in the form of steroid and intravenous immunoglobulin. Such measures helped stabilize his bleeding and allowed urgent neurosurgical intervention. Competing Interests: The authors declare no conflicts of interest. (© 2020 Publishing services provided by Elsevier B.V. on behalf of King Faisal Specialist Hospital & Research Centre (General Organization), Saudi Arabia.) |
| Databáze: | MEDLINE |
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