HIV-exposed infants with EBV infection have a reduced persistence of the immune response to the HBV vaccine.

Autor: Baroncelli S; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy. silvia.baroncelli@iss.it., Galluzzo CM; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy., Liotta G; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy., Andreotti M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy., Orlando S; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Via Montpellier, 1, 00133, Rome, Italy., Ciccacci F; Saint Camillus International University of Health Sciences, Rome, Italy., Mphwere R; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi., Luhanga R; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi., Sagno JB; DREAM Program, Community of S. Egidio, P.O. Box 30355, Blantyre, Malawi., Amici R; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy., Marazzi MC; Department of Human Sciences, LUMSA University, Via Traspontina 21, 00193, Rome, Italy., Giuliano M; National Center for Global Health, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161, Rome, Italy.
Jazyk: angličtina
Zdroj: AIDS research and therapy [AIDS Res Ther] 2021 Aug 04; Vol. 18 (1), pp. 48. Date of Electronic Publication: 2021 Aug 04.
DOI: 10.1186/s12981-021-00375-7
Abstrakt: Background: In sub-Saharan African countries Epstein Barr virus (EBV) infection occurs in early childhood. We aim to investigate the factors associated with EBV acquisition and the impact of EBV infection on the humoral response to HBV vaccination in infants born from HIV-positive, antiretroviral-treated mothers in Malawi.
Methods: A total of 149 HIV-exposed infants were included in this longitudinal study. EBV anti-VCA IgG were measured using an ELISA assay. The EBV seroconversion was correlated with the maternal viro-immunological conditions, with infant growth and immunological vulnerability, and with the humoral response to the HBV vaccine.
Results: No infant was EBV-positive at 6 months (n. 52 tested). More than a third of infants (49/115 or 42.6 %) on study beyond 6 months seroconverted at 12 months. At 24 months, out of 66 tested infants, only 13 remained EBV-uninfected, while 53 (80.3 %) acquired EBV infection, rising the total proportion of EBV seroconversion to 88.7 % (102/115 infants). EBV seroconversion was significantly associated with a low maternal educational status but had no impact on infant growth or vulnerability to infections. Reduced HBsAb levels and accelerated waning of antibodies were associated with early EBV seroconversion.
Conclusions: We found a heterogeneous timing of acquisition of EBV with the majority of infants born from HIV + mothers acquiring infection after 6 months. Anti-HBs levels were lower and appeared to wane faster in infants acquiring EBV infection.
(© 2021. The Author(s).)
Databáze: MEDLINE
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