Correlations between bladder wall thickness and clinical manifestations in female patients with detrusor underactivity and detrusor overactivity-with-detrusor underactivity.

Autor:	Yu PH; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC., Lin CC; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Fan YH; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Lin ATL; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC., Huang WJS; Department of Urology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.; Department of Urology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.; Shu-Tien Urological Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.
Jazyk:	angličtina
Zdroj:	Journal of the Chinese Medical Association : JCMA [J Chin Med Assoc] 2021 Oct 01; Vol. 84 (10), pp. 937-941.
DOI:	10.1097/JCMA.0000000000000593
Abstrakt:	Background: Among female patients with lower urinary tract symptoms, detrusor underactivity (DU), and detrusor overactivity-with-detrusor underactivity (DO-DU) are two common diagnoses. Here, we investigated the correlations between bladder wall thickness (BWT) and clinical manifestations of the two diagnoses. Methods: From 2011 to 2016, female patients with DU or DO-DU, diagnosed at our institute, were recruited. We analyzed their urodynamic parameters and collected three questionnaires (IPSS, UDI-6, OABSS). Using transabdominal sonography, the BWT was recorded. DU was defined as follows: maximum free flow rate (Qmax) ≤ 15 cc/s; detrusor pressure at maximum flow (PdetQmax) ≤ 20 cmH2O; bladder capacity > 150 cc. DO-DU was defined as follows: Qmax ≤ 15 cc/s; PdetQmax ≤ 20 cmH2O; bladder capacity ≤ 150 cc. The BWTs of the two groups were compared using the Mann-Whitney U test; the correlations among the BWTs and the results of three questionnaires were analyzed using Spearman's rank correlation coefficient. Results: Forty-eight female patients with DU and 13 with DO-DU were recruited. Demographic data revealed no differences between the two groups. The mean BWT of the DO-DU patients was significantly larger than that of the DU patients (4.11 vs 3.42 mm; p = 0.001). In the DO-DU group, a high correlation existed between the BWT and some of the UDI-6 items (urgency incontinence: r = 0.831, p = 0.006; incontinence related to activity: r = 0.884, p = 0.002; small amounts of leakage: r = 0.809, p = 0.008). The BWT of the DO-DU patients also exhibited a moderate correlation with the urgency incontinence from the OABSS questionnaire (r = 0.679; p = 0.044). No correlations existed between the BWT of the DU patients and any of the data from the three questionnaires. Conclusion: The BWT in the DO-DU patients was significantly thicker than that in the DU patients. The DO-DU patients with thicker bladder walls also had higher UDI-6 scores for both urgency and urgency incontinence. Competing Interests: Conflicts of interest: Dr. William J. S. Huang, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The other authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article. (Copyright © 2021, the Chinese Medical Association.)
Databáze:	MEDLINE
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