| Autor: |
Puleo TR; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States., Klaus DR; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States., Bandar JS; Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States. |
| Abstrakt: |
We report a general protocol for the direct C-H etherification of N -heteroarenes. Potassium tert -butoxide catalyzes halogen transfer from 2-halothiophenes to N -heteroarenes to form N -heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions. |
