XPS and ToF-SIMS Characterization of New Biodegradable Poly(Peptide-Urethane-Urea) Block Copolymers.

Autor: Zorn G; Department of Chemical Engineering, University of Washington, Seattle, WA, 98195-1750, USA.; General Electric Research, One Research Circle, Niskayuna, NY, 12309, USA., Simonovsky FI; Department of Bioengineering, University of Washington, Seattle, WA, 98195-5061, USA., Ratner BD; Department of Chemical Engineering, University of Washington, Seattle, WA, 98195-1750, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195-5061, USA., Castner DG; Department of Chemical Engineering, University of Washington, Seattle, WA, 98195-1750, USA.; Department of Bioengineering, University of Washington, Seattle, WA, 98195-5061, USA.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2022 May; Vol. 11 (9), pp. e2100894. Date of Electronic Publication: 2021 Aug 04.
DOI: 10.1002/adhm.202100894
Abstrakt: New, linear, segmented poly(peptide-urethane-urea) (PPUU) block copolymers are synthesized and their surface compositions are characterized with angle dependent X-ray photoelectron spectroscopy (ADXPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS). These new PPUU block copolymers contain three types of segments. The soft segment (SS) is poly(caprolactone diol) (PCL). The hard segment is lysine diisocyanate with a hydrazine chain extender. The oligopeptide segment (OPS) contains three types of amino acids (proline, hydroxyproline, and glycine). Incorporation of the OPS into the polyurethane backbone is done to provide a synthetic polymer material with controllable biodegradation properties. As biodegradation processes normally are initiated at the interface between the biomaterial and the living tissue, it is important to characterize the surface composition of biomaterials. ADXPS and ToF-SIMS results show that the surfaces of all four polymers are enriched with the PCL SS, the most hydrophobic component of the three polymer segments.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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