Error-related negativity predicts increases in anxiety in a sample of clinically anxious female children and adolescents over 2 years.

Autor:	Meyer A; From the Department of Psychology, Florida State University Ringgold Standard Institution, Tallahassee, FL (Meyer, Mehra, Hajcak)., Mehra L; From the Department of Psychology, Florida State University Ringgold Standard Institution, Tallahassee, FL (Meyer, Mehra, Hajcak)., Hajcak G; From the Department of Psychology, Florida State University Ringgold Standard Institution, Tallahassee, FL (Meyer, Mehra, Hajcak).
Jazyk:	angličtina
Zdroj:	Journal of psychiatry & neuroscience : JPN [J Psychiatry Neurosci] 2021 Aug 04; Vol. 46 (4), pp. E472-E479. Date of Electronic Publication: 2021 Aug 04.
DOI:	10.1503/jpn.200128
Abstrakt:	Background: An increased neural response to making errors has emerged as a biomarker of anxiety. Error negativity (Ne) or errorrelated negativity (ERN) is an event-related potential generated when people commit errors; the Ne/ERN is greater among people with anxiety and predicts increases in anxiety. However, no previous study has examined whether the Ne/ERN can be used as a prognostic indicator among people with current anxiety. The present study addressed this gap by examining whether the Ne/ERN prospectively predicts increases in anxiety symptoms in clinically anxious children and adolescents. Methods: The sample included 34 female participants between the ages of 8 and 14 years who met the criteria for a clinical anxiety disorder based on clinical interview. The Ne/ERN was measured using a flanker task. Results: Increased Ne/ERN at baseline predicted increases in total anxiety symptoms 2 years later, even when accounting for baseline symptoms. The Ne/ERN predicted increases in the symptom domains of generalized anxiety, social anxiety and harm avoidance/perfectionism, but not panic, separation anxiety, school avoidance or physical symptoms. Limitations: The sample size was small, which may have inflated the false discovery rate. To mitigate this possibility, we used multiple self-report measures, and the results for the 2 measures (as well as their symptom domains) converged. Conclusion: These data suggest that the Ne/ERN can delineate specific risk trajectories, even among those who already meet the criteria for a clinical anxiety disorder. Considering the need for prognostic markers among people with clinical anxiety, the current findings are an important and novel extension of previous work. Competing Interests: None declared. (© 2021 CMA Joule Inc. or its licensors.)
Databáze:	MEDLINE
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