Cellular and Molecular Comparison of Glioblastoma Multiform Cell Lines.

Autor:	Demircan T; Genetics, Muğla Sıtkı Koçman University, Muğla, TUR., Yavuz M; Institute of Health Sciences, Muğla Sıtkı Koçman University, Muğla, TUR., Kaya E; Surgery, Mugla Sitki Kocman University, Muğla, TUR., Akgül S; Institute of Health Sciences, Aydın Adnan Menderes University, Aydın, TUR., Altuntaş E; Institute of Natural Sciences, Muğla Sıtkı Koçman University, Muğla, TUR.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Jun 29; Vol. 13 (6), pp. e16043. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).
DOI:	10.7759/cureus.16043
Abstrakt:	Glioblastoma multiform (GBM) is one of the most severe tumor types. It is highly invasive and characterized as a grade IV neoplastic cancer. Its resistance to chemotherapy-temozolomide (TMZ treatment)-in combination with tumor treating fields (TTFields), limits the cure of GBM. Therefore researchers are searching for new treatment options to increase the length of recurrence time and improve overall survival for GBM patients. Several cell lines have been established and are in use to understand the molecular basis of GBM and to test the developed drugs. On one hand, it is highly advantageous to utilize multiple cell lines with different genetic backgrounds to gain more insight into the characterization and treatment of the disease. However, on the other hand, characteristics of these cell lines such as proliferation rate, invasion, and colony formation capacity differ greatly among these cells. Hence, a detailed comparison concerning molecular and cellular features of commonly used cell lines is essential. In this study, cell proliferation and apoptosis rate, cell migration capacity, and gene expression profile of U87, Ln229, and SvGp12 cells have been investigated and compared. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Demircan et al.)
Databáze:	MEDLINE
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