Supratentorial lymphocytic inflammation with parenchymal perivascular enhancement responsive to steroids: A case report and literature review.

Autor:	Sudhakar V; Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States., Gersey Z; Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States., Polster SP; Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States., Mantica M; Department of Neurology and Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States., Zenonos G; Department of Neurological Surgery University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States.
Jazyk:	angličtina
Zdroj:	Surgical neurology international [Surg Neurol Int] 2021 Jul 06; Vol. 12, pp. 327. Date of Electronic Publication: 2021 Jul 06 (Print Publication: 2021).
DOI:	10.25259/SNI_355_2021
Abstrakt:	Background: Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids is a rare disorder that presents with subacute brainstem symptoms such as ataxia, facial paresthesias, and episodic diplopia, thought to be due to a T-cell medicated perivascular inflammatory process. A supratentorial variant, Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids (SLIPPERS), has been described in only three patients. Case Description: A 71-year-old male presented with word-finding difficulties, confusion, and left leg weakness. Radiographic workup demonstrated multiple supratentorial ring-enhancing lesions. PET/CT demonstrated hypermetabolism and susceptibility-weighted imaging demonstrated a hemorrhagic component. Frozen pathology revealed a predominately T-cell and monocyte inflammatory infiltrate. He demonstrated interval improvement to dexamethasone therapy, but then demonstrated worsening of his symptoms following discontinuation. Conclusion: Given his dramatic response to corticosteroids, he was diagnosed with SLIPPERS. SLIPPERS is an underrecognized diagnostic entity to consider in patients with ring-enhancing lesions and can present with hypermetabolic lesions on PET/CT. Competing Interests: There are no conflicts of interest. (Copyright: © 2021 Surgical Neurology International.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu