[Posterior reversible encephalopathy syndrome in critical COVID-19 patients: Report of 2 cases].

Autor:	Tortajada Soler JJ; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España., Tauler Redondo MP; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España., Garví López M; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España., Lozano Serrano MB; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España., López-Torres López J; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España., Sánchez López ML; Servicio de Anestesiología, Reanimación y Terapéutica del Dolor, Hospital General Universitario de Albacete, Albacete, España.
Jazyk:	Spanish; Castilian
Zdroj:	Revista espanola de anestesiologia y reanimacion [Rev Esp Anestesiol Reanim] 2023 Jan; Vol. 70 (1), pp. 51-55. Date of Electronic Publication: 2021 Jul 30.
DOI:	10.1016/j.redar.2021.05.022
Abstrakt:	Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier, cerebral hypoperfusion, and vasogenic edema.The cases are presented on 2 critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging compatible with posterior reversible encephalopathy syndrome.SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between posterior reversible encephalopathy syndrome and COVID-19. (© 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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