Cognitive deficits and clinical symptoms in patients with treatment-refractory obsessive-compulsive disorder: The role of slowness in information processing.

Autor: Simón-Martínez V; General Hospital of the Defense, Zaragoza, Spain., Laseca-Zaballa G; Department Experimental Psychology, Complutense University of Madrid, Spain., Lubrini G; Department Experimental Psychology, Complutense University of Madrid, Spain., Periáñez JA; Department Experimental Psychology, Complutense University of Madrid, Spain., Martínez Álvarez R; Department of Radiosurgery and Functional Neurosurgery, Ruber International Hospital, Madrid, Spain., Torres-Díaz CV; Department of Radiosurgery and Functional Neurosurgery, Ruber International Hospital, Madrid, Spain., Martínez Moreno N; Department of Radiosurgery and Functional Neurosurgery, Ruber International Hospital, Madrid, Spain., Álvarez-Linera J; Department of Radiodiagnosis, Ruber International Hospital, Madrid, Spain., Ríos-Lago M; Department Basic Psychology II, UNED, Madrid, Spain; Brain Damage Service, Beata Maria Ana Hospital, Madrid, Spain. Electronic address: mrios@psi.uned.es.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2021 Oct; Vol. 304, pp. 114143. Date of Electronic Publication: 2021 Jul 26.
DOI: 10.1016/j.psychres.2021.114143
Abstrakt: Patients with Obsessive-Compulsive Disorder (OCD) present neuropsychological deficits across different cognitive domains, especially in executive functioning and information processing speed. Some studies have even suggested that speed deficits may underlie poor neuropsychological performance. However, this hypothesis remains unanswered in both OCD general population and OCD refractory subgroup. In addition, it is not clear whether such deficits are secondary to the clinical symptoms or may constitute a primary deficit. The aim of this study was to explore the speed of processing hypothesis in treatment-refractory OCD patients, and to clarify to what extent slowness is related to psychopathological symptoms. Both clinical and neuropsychological examination was conducted to assess 39 OCD refractory patients candidates for neurosurgery and 39 healthy matched individuals. Principal component analysis revealed a three-component structure in the neuropsychological battery being used, including a speed of processing, working memory, and conflict monitoring components. Group comparisons revealed that OCD patients performed significantly worse than healthy individuals in speed measures, but no differences were found in executive tests not influenced by time. Correlation analyses revealed a lack of association between neuropsychological and clinical measures. The results suggest that treatment-refractory OCD patients exhibit a primary deficit in information processing speed independent of clinical symptoms.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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