Observed birth prevalence of congenital anomalies among live births at a regional facility in KwaZulu Natal Province, South Africa.

Autor: Saib MZ; KwaZulu Natal Department of Health, Paediatrics and Child Health, Grey's Hospital, Pietermaritzburg, South Africa.; Paediatrics & Child Health, Nelson R Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa., Dhada BL; KwaZulu Natal Department of Health, Paediatrics and Child Health, Grey's Hospital, Pietermaritzburg, South Africa.; Paediatrics & Child Health, Nelson R Mandela School of Clinical Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa., Aldous C; School of Clinical Medicine, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa., Malherbe HL; KwaZulu Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu Natal, Durban, South Africa.; Rare Diseases South Africa NPC, Johannesburg, South Africa.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Aug 03; Vol. 16 (8), pp. e0255456. Date of Electronic Publication: 2021 Aug 03 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0255456
Abstrakt: Congenital disorders (CDs), defined as abnormalities in structure or function present at birth, are an important contributor to the disease burden in developing countries. The size and extent of the problem in South Africa (SA) are unknown due to the lack of recent, reliable, observed data on CDs. To address this empirical data gap, this study aimed to measure the birth prevalence of congenital anomalies (a sub-set of CDs) and to describe the pattern of these anomalies at a regional hospital in KwaZulu Natal (KZN), SA. A retrospective, observational, descriptive review of congenital anomalies diagnosed within the neonatal service at Edendale Hospital (EDH), KZN was undertaken between January and December 2018. All EDH in-house live births diagnosed and notified with congenital anomalies by discharge were included. Stillbirths, other pregnancy losses and out-born neonates were excluded. Data were actively collected from the birth register, neonatal admission register, and the individual paper-based surveillance tool developed by the National Department of Health. The in-facility birth prevalence rate for congenital anomalies was 15.57 per 1 000 live births. The most observed system was musculoskeletal (32%) followed by circulatory system anomalies (19%). When the observed birth prevalence rates of key congenital anomalies were compared with previously published, modelled South African data, no significant difference was found. This study responds to the paucity of birth prevalence data on CDs overall and offers evidence that obvious, structural CDs (congenital anomalies) need to be addressed in the SA public health system.
Competing Interests: Muhammad Zubayr Saib declares no conflict of interest. Barnesh L Dhada declares no conflict of interest. Colleen Aldous declares no conflict of interest. Helen L Malherbe was the Honorary Chair of Genetic Alliance South Africa (NPO: 001-029) until March 2020 and was appointed as a (Honorary) Director of Rare Diseases South Africa in April 2020 The authors declare that this does not alter our adherence to PLOS ONE policies on sharing data and materials.
Databáze: MEDLINE
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