Multiscale Dynamic Structuring of Bacterial Chromosomes.
| Autor: | Lioy VS; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France; email: frederic.boccard@i2bc.paris-saclay.fr., Junier I; Université Grenoble Alpes, CNRS, TIMC-IMAG, 38000 Grenoble, France., Boccard F; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France; email: frederic.boccard@i2bc.paris-saclay.fr. |
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| Jazyk: | angličtina |
| Zdroj: | Annual review of microbiology [Annu Rev Microbiol] 2021 Oct 08; Vol. 75, pp. 541-561. Date of Electronic Publication: 2021 Aug 03. |
| DOI: | 10.1146/annurev-micro-033021-113232 |
| Abstrakt: | Since the nucleoid was isolated from bacteria in the 1970s, two fundamental questions emerged and are still in the spotlight: how bacteria organize their chromosomes to fit inside the cell and how nucleoid organization enables essential biological processes. During the last decades, knowledge of bacterial chromosome organization has advanced considerably, and today, such chromosomes are considered to be highly organized and dynamic structures that are shaped by multiple factors in a multiscale manner. Here we review not only the classical well-known factors involved in chromosome organization but also novel components that have recently been shown to dynamically shape the 3D structuring of the bacterial genome. We focus on the different functional elements that control short-range organization and describe how they collaborate in the establishment of the higher-order folding and disposition of the chromosome. Recent advances have opened new avenues for a deeper understanding of the principles and mechanisms of chromosome organization in bacteria. |
| Databáze: | MEDLINE |
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