Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children.

Autor:	Han AX; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands., Felix Garza ZC; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands., Welkers MR; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands., Vigeveno RM; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands., Tran ND; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Le TQM; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Pham Quang T; National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam., Dang DT; Ha Nam Centre for Disease Control, Ha Nam, Viet Nam., Tran TNA; Children's Hospital 2, Ho Chi Minh city, Viet Nam., Ha MT; Children's Hospital 2, Ho Chi Minh city, Viet Nam., Nguyen TH; Children's Hospital 1, Ho Chi Minh city, Viet Nam., Le QT; Children's Hospital 1, Ho Chi Minh city, Viet Nam., Le TH; Vietnam National Children's Hospital, Hanoi, Viet Nam., Hoang TBN; Vietnam National Children's Hospital, Hanoi, Viet Nam., Chokephaibulkit K; Siriraj Hospital, Mahidol University, Bangkok, Thailand., Puthavathana P; Siriraj Hospital, Mahidol University, Bangkok, Thailand., Nguyen VVC; Hospital for Tropical Diseases, Ho Chi Minh city, Viet Nam., Nghiem MN; Hospital for Tropical Diseases, Ho Chi Minh city, Viet Nam., Nguyen VK; National Hospital for Tropical Diseases, Hanoi, Viet Nam., Dao TT; National Hospital for Tropical Diseases, Hanoi, Viet Nam., Tran TH; Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Oxford University Clinical Research Unit, Ho Chi Minh city, Viet Nam., Wertheim HF; Oxford University Clinical Research Unit, Ho Chi Minh city, Viet Nam.; Radboud Medical Centre, Radboud University, Nijmegen, Netherlands.; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom., Horby PW; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hanoi, Viet Nam., Fox A; Oxford University Clinical Research Unit, Hanoi, Viet Nam.; Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Australia.; WHO Collaborating Centre for Reference and Research on Influenza, Melbourne, Australia., van Doorn HR; Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.; Oxford University Clinical Research Unit, Hanoi, Viet Nam., Eggink D; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands.; Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, Netherlands., de Jong MD; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands., Russell CA; Department of Medical Microbiology & Infection Prevention, Amsterdam University Medical Center, Amsterdam, Netherlands.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Aug 03; Vol. 10. Date of Electronic Publication: 2021 Aug 03.
DOI:	10.7554/eLife.68917
Abstrakt:	The evolution of influenza viruses is fundamentally shaped by within-host processes. However, the within-host evolutionary dynamics of influenza viruses remain incompletely understood, in part because most studies have focused on infections in healthy adults based on single timepoint data. Here, we analyzed the within-host evolution of 82 longitudinally sampled individuals, mostly young children, infected with A/H1N1pdm09 or A/H3N2 viruses between 2007 and 2009. For A/H1N1pdm09 infections during the 2009 pandemic, nonsynonymous minority variants were more prevalent than synonymous ones. For A/H3N2 viruses in young children, early infection was dominated by purifying selection. As these infections progressed, nonsynonymous variants typically increased in frequency even when within-host virus titers decreased. Unlike the short-lived infections of adults where de novo within-host variants are rare, longer infections in young children allow for the maintenance of virus diversity via mutation-selection balance creating potentially important opportunities for within-host virus evolution. Competing Interests: AH, ZF, MW, RV, NT, TL, TP, DD, TT, MH, TN, QL, TL, TH, KC, PP, VN, MN, VN, TD, TT, HW, PH, AF, Hv, DE, Md, CR No competing interests declared (© 2021, Han et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu