Improvement of Skin Barrier Dysfunction by Phenolic-containing Extracts of Lycium barbarum via Nrf2/HO-1 Regulation.

Autor: Liu GT; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China., Li YL; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China., Wang J; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China., Dong CZ; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.; Sorbonne Paris Cité, ITODYS, UMR 7086 CNRS, Université Paris Diderot, Paris, France., Deng M; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China., Tai M; Infinitus (China) Co. Ltd., Guangzhou, China., Deng L; Infinitus (China) Co. Ltd., Guangzhou, China., Che B; Infinitus (China) Co. Ltd., Guangzhou, China., Lin L; Foshan Conney Allan Biotechnology Co. Ltd, Foshan, China., Du ZY; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China., Chen HX; The School of Biomedical and Pharmaceutical Engineering, Guangdong University of Technology, Guangzhou, China.; Chemistry of RNA, Nucleosides, Peptides and Heterocycles, CNRS UMR8601, Université Paris Descartes, PRES Sorbonne Paris Cité, UFR Biomédicale, Paris Cedex 06, France.
Jazyk: angličtina
Zdroj: Photochemistry and photobiology [Photochem Photobiol] 2022 Jan; Vol. 98 (1), pp. 262-271. Date of Electronic Publication: 2021 Aug 12.
DOI: 10.1111/php.13498
Abstrakt: Lycium barbarum have received an increasing popularity due to its powerful biological activity and medicinal use. However, the effect of Lycium barbarum on skin remains largely uncharacterized. The general purpose of this paper was to characterize the phenolic compounds in Lycium barbarum extract (LBE) using LC-HRMS/QTOF method and to investigate whether topical administration of LBE can repair skin barrier dysfunction in mice. Our data demonstrated that LBE could not only decrease ROS level and matrix metalloproteinase expression, but also strengthen intrinsic antioxidant defense system including SOD, GSH-Px and CAT, thereby resulting in increased skin collagen content and an improvement of UV-induced skin erythema, thickness and wrinkles. Improved skin barrier functions were highly correlated with increased expression of filaggrin, involucrin and loricrin as well as antioxidant proteins such as Nrf2 and HO-1 in UV-irradiated mice, suggesting that LBE may be promising natural products at a lower cost for the topical application in the treatment of skin diseases with defective barrier function.
(© 2021 American Society for Photobiology.)
Databáze: MEDLINE
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