CT-defined emphysema in COPD patients and risk for change in desaturation status in 6-min walk test.
| Autor: | Waatevik M; Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway. Electronic address: marie.waatevik@helse-bergen.no., Frisk B; Dept of Health and Functioning, Western Norway University of Applied Sciences, Bergen, Norway; Dept of Physiotherapy, Haukeland University Hospital, Bergen, Norway., Real FG; Dept of Clinical Science, University of Bergen, Bergen, Norway; Dept of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway., Hardie JA; Dept of Clinical Science, University of Bergen, Bergen, Norway., Bakke P; Dept of Clinical Science, University of Bergen, Bergen, Norway., Eagan TM; Dept of Clinical Science, University of Bergen, Bergen, Norway; Dept of Thoracic Medicine, Haukeland University Hospital, Bergen, Norway., Johannessen A; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. |
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| Jazyk: | angličtina |
| Zdroj: | Respiratory medicine [Respir Med] 2021 Oct; Vol. 187, pp. 106542. Date of Electronic Publication: 2021 Jul 23. |
| DOI: | 10.1016/j.rmed.2021.106542 |
| Abstrakt: | Background: Emphysema and exercise induced desaturation (EID) are both related to poorer COPD prognosis. More knowledge of associations between emphysema and desaturation is needed for more efficient disease management. Research Question: Is emphysema a risk factor for both new and repeated desaturation, and is emphysema of more or less importance than other known risk factors? Methods: 283 COPD patients completed a 6-min walk test (6MWT) at baseline and one year later in the Bergen COPD cohort study 2006-2011. Degree of emphysema was assessed as percent of low attenuation areas (%LAA) under -950 Hounsfield units using high-resolution computed tomography at baseline. We performed multinomial logistic regression analysis, receiver operating curves (ROC) and area under the curve (AUC) estimations. Dominance analysis was used to rank emphysema and risk factors in terms of importance. Results: A one percent increase in %LAA increases the relative risk (RR) of new desaturation by 10 % (RR 1.1 (95%CI 1.1, 1.2)) and for repeated desaturation by 20 % (RR 1.2 (95%CI 1.1, 1.3)). Compared with other important desaturation risk factors, %LAA ranked as number one in the dominance analysis, accounting for 50 % and 37 % of the predicted variance for new and repeated desaturators, respectively. FEV Conclusion: Emphysema increases the risk of developing and repeatedly experiencing EID. Emphysema seems to be a more important risk factor for desaturation than FEV (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| Databáze: | MEDLINE |
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