Multivariate analysis of oocyte donor and recipient factors affecting cumulative live birth rate in oocyte donor IVF (OD-IVF) cycles.

Autor:	Malhotra N; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Gupta M; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Yadav A; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Jaiswal P; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Bansiwal R; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Singh N; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Upadhyay AD; Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India., Bhatt A; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India., Mahey R; Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2021 Oct 04; Vol. 25 (4), pp. 549-556. Date of Electronic Publication: 2021 Oct 04.
DOI:	10.5935/1518-0557.20210027
Abstrakt:	Objective: To study donor and recipient factors affecting cumulative live birth rate (CLBR) in oocyte donor IVF (OD- IVF) cycles. Methods: The present retrospective study was conducted at the ART center of a tertiary care referral hospital after ethical approval, and included all OD-IVF cycles done between January 2014 - October 2019. Donor parameters included age, body mass index (BMI), ovarian reserve markers, serum estradiol (E2) on trigger day, and number of total/grade 1 oocytes; recipient parameters included age and BMI. The primary outcome was CLBR resulting from one complete donor-recipient (D-R) cycle through fresh/frozen embryo transfer. Secondary outcomes included number of total and grade 1 oocytes, fertilization rate, cleavage rate and clinical pregnancy rate (CPR). Results: We analyzed 262 D-R cycles for donor characteristics and 260 cycles for CLBR. The mean age of the recipients was 35.20±4.05, and for donors it was 25.29±2.03 years. The CPR and CLBR per started cycle was 60% and 55.7%, respectively. Recipient BMI and grade 1 oocytes were found to be independent predictors of CLBR in multivariate analysis. As the number of grade 1 oocytes increased, the likelihood of live births increased by 10% (95% CI, 1.04 - 1.32, p=0.008). Recipient BMI ≥25kg/m2 reduced the chances of CLBR by 50% (95% CI, 0.27 - 0.81, p=0.007). Conclusions: Number of grade 1 oocytes and recipient BMI significantly affect CLBR in OD-IVF cycles. Recipients with BMI ≥25kg/m² may be advised to lose weight and improve CLBR likelihood.
Databáze:	MEDLINE
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