Living Organ Donor Perspectives and Sources of Hesitancy about COVID-19 Vaccines.

Autor:	Harhay MN; Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.; Department of Epidemiology and Biostatistics, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania.; Division of Nephrology, Tower Health Transplant Institute, Tower Health System, West Reading, Pennsylvania., Klassen AC; Department of Community Health and Prevention, Drexel University Dornsife School of Public Health, Philadelphia, Pennsylvania., Zaidi H; Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania., Mittelman M; American Living Organ Donor Fund, Philadelphia, Pennsylvania., Bertha R; American Living Organ Donor Fund, Philadelphia, Pennsylvania., Mannon RB; Division of Nephrology, Department of Medicine, University of Nebraska Medical Center, Omaha, Nebraska., Lentine KL; Saint Louis University Center for Abdominal Transplantation, Saint Louis University School of Medicine, St. Louis, Missouri.
Jazyk:	angličtina
Zdroj:	Kidney360 [Kidney360] 2021 Jul; Vol. 2 (7), pp. 1132-1140.
DOI:	10.34067/KID.0002112021
Abstrakt:	Background: Living organ donation declined substantially in the United States during the COVID-19 pandemic due to concerns about donor and transplant candidate safety. COVID-19 vaccines might increase confidence in the safety of living organ donation during the pandemic. We assessed informational preferences and perspectives about COVID-19 vaccines among US living organ donors and prospective donors. Methods: We conducted a national survey study of organ donors and prospective donors on social media platforms between 12/28/2020-2/23/2021. Survey items included multiple choice, visual analog scale, and open-ended responses. We examined associations between information preferences, history of COVID-19 infection, influenza vaccination history and COVID-19 vaccine acceptance using multivariable logistic regression and performed a thematic analysis of open-ended responses. Results: Among 342 respondents from 47 US states and the District of Columbia, 35% were between 51-70 years old, 90% were non-Hispanic white, 87% were women; 82% were living donors (94% kidney) and 18% in evaluation to donate (75% kidney).The majority planned to or had received COVID-19 vaccination (76%), whereas 11% did not plan to be receive a vaccine, and 12% were unsure. Adjusting for demographics and donor characteristics, respondents who receive yearly influenza vaccinations had higher COVID-19 vaccine acceptance than those who do not (adjusted Odds Ratio [aOR] 5.06, 95% Confidence Interval [CI] 2.68-9.53). Compared to respondents who prioritized medical information sources (e.g., personal physicians and transplant providers), those who prioritized news and social media had lower COVID-19 vaccine acceptance (aOR 0.34, 95% CI 0.15-0.73). Low perceived personal benefit from vaccination and uncertainty about long-term safety were common themes among those declining COVID-19 vaccines. Conclusions: Donor informational source preferences were strongly associated with the likelihood of accepting a COVID-19 vaccine. Vaccine guidance for organ donors who are unsure about COVID-19 vaccines could incorporate messaging about safety and benefits of vaccination for healthy people. Competing Interests: Disclosures: The authors declare that they have no financial conflicts of interest. MM reports a consulting relationship with Pfizer, Incorporated. Dr. Klassen reports consultant work with Merck, Sharpe, and Dome (a manufacturer of a COVID-19 vaccine).
Databáze:	MEDLINE
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