Genetic association study of childhood aggression across raters, instruments, and age.
| Autor: | Ip HF; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., van der Laan CM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Netherlands Institute for the Study of Crime and Law Enforcement, Amsterdam, The Netherlands., Krapohl EML; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Brikell I; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Sánchez-Mora C; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Nolte IM; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., St Pourcain B; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Max Planck Institute for Psycholinguistics, Nijmegen, The Netherlands.; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands., Bolhuis K; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands., Palviainen T; Institute for Molecular Medicine FIMM, HiLife, University of Helsinki, Helsinki, Finland., Zafarmand H; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Colodro-Conde L; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Gordon S; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Zayats T; Department of Biomedicine, University of Bergen, Bergen, Norway.; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aliev F; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.; Faculty of Business, Karabuk University, Karabuk, Turkey., Jiang C; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.; Department of Biostatistics, University of Florida, Gainesville, FL, USA., Wang CA; Faculty of Medicine and Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia., Saunders G; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Karhunen V; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Hammerschlag AR; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Child Health Research Centre, the University of Queensland, Brisbane, QLD, Australia.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands., Adkins DE; Department of Sociology, College of Social and Behavioral Science, University of Utah, Salt Lake City, UT, USA.; Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City, UT, USA., Border R; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA.; Department of Applied Mathematics, University of Colorado Boulder, Boulder, CO, USA., Peterson RE; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Prinz JA; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA., Thiering E; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Division of Metabolic Diseases and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany., Seppälä I; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Vilor-Tejedor N; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Barcelona, Spain.; Barcelona Beta Brain Research Center, Pasqual Maragall Foundation (FPM), Barcelona, Spain., Ahluwalia TS; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.; Steno Diabetes Center Copenhagen, Gentofte, Denmark., Day FR; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge, UK., Hottenga JJ; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Allegrini AG; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Rimfeld K; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Chen Q; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lu Y; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Martin J; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Soler Artigas M; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Rovira P; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Bosch R; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain., Español G; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain., Ramos Quiroga JA; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain., Neumann A; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, QC, Canada., Ensink J; Department of Child and Adolescent Psychiatry, Academic Medical Center, Amsterdam, The Netherlands.; De Bascule, Academic Centre for Child and Adolescent Psychiatry, Amsterdam, The Netherlands., Grasby K; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Morosoli JJ; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Tong X; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.; Department of Biostatistics, University of Florida, Gainesville, FL, USA., Marrington S; School of Public Health, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia., Middeldorp C; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Child Health Research Centre, the University of Queensland, Brisbane, QLD, Australia.; Children's Health Queensland Hospital and Health Service, Child and Youth Mental Health Service, Brisbane, QLD, Australia., Scott JG; School of Public Health, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia.; Metro North Mental Health, University of Queensland, St Lucia, QLD, Australia.; Queensland Centre for Mental Health Research, St Lucia, QLD, Australia., Vinkhuyzen A; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Shabalin AA; Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City, UT, USA., Corley R; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Evans LM; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Ecology and Evolutionary Biology, University of Colorado Boulder, Boulder, CO, USA., Sugden K; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA., Alemany S; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Sass L; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Vinding R; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Ruth K; Genetics of Complex Traits, Royal Devon & Exeter Hospital, University of Exeter Medical School, Exeter, UK., Tyrrell J; Genetics of Complex Traits, Royal Devon & Exeter Hospital, University of Exeter Medical School, Exeter, UK., Davies GE; Avera Institute for Human Genetics, Sioux Falls, SD, USA., Ehli EA; Avera Institute for Human Genetics, Sioux Falls, SD, USA., Hagenbeek FA; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., De Zeeuw E; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Van Beijsterveldt TCEM; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Larsson H; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.; School of Medical Sciences, Orebro University, Orebro, Sweden., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Verhulst FC; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, Research Unit, Copenhagen University Hospital, Copenhagen, Denmark., Amin N; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands., Whipp AM; Institute for Molecular Medicine FIMM, HiLife, University of Helsinki, Helsinki, Finland., Korhonen T; Institute for Molecular Medicine FIMM, HiLife, University of Helsinki, Helsinki, Finland., Vuoksimaa E; Institute for Molecular Medicine FIMM, HiLife, University of Helsinki, Helsinki, Finland., Rose RJ; Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA., Uitterlinden AG; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands.; Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands., Heath AC; Washington University, St Louis, MO, USA., Madden P; Washington University, St Louis, MO, USA., Haavik J; Department of Biomedicine, University of Bergen, Bergen, Norway.; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway., Harris JR; Division of Health Data and Digitalisation, The Norwegian Institute of Public Health, Oslo, Norway., Helgeland Ø; Department of Genetics and Bioinformatics, Division of Health Data and Digitalization, The Norwegian Institute of Public Health, Bergen, Norway., Johansson S; Department of Biomedicine, University of Bergen, Bergen, Norway.; K.G. Jebsen Centre for Neuropsychiatric Disorders, Department of Clinical Science, University of Bergen, Bergen, Norway., Knudsen GPS; Division of Health Data and Digitalisation, The Norwegian Institute of Public Health, Oslo, Norway., Njolstad PR; Department of Clinical Science, University of Bergen, Bergen, Norway., Lu Q; Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.; Department of Biostatistics, University of Florida, Gainesville, FL, USA., Rodriguez A; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; School of Psychology, University of Lincoln, Lincolnshire, UK., Henders AK; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Mamun A; Institute for Social Science Research, University of Queensland, Long Pocket, QLD, Australia., Najman JM; School of Public Health, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia., Brown S; Department of Psychiatry, University of California, San Diego, CA, USA., Hopfer C; University of Colorado School of Medicine, Aurora, CO, USA., Krauter K; Department of Molecular, Cellular, and Developmental Biology, University of Colorado Boulder, Boulder, CO, USA., Reynolds C; Department of Psychology, University of California Riverside, Riverside, CA, USA., Smolen A; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Stallings M; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Wadsworth S; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA., Wall TL; Department of Psychiatry, University of California, San Diego, CA, USA., Silberg JL; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human & Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Miller A; Department of Pathology and Biomedical Science, and Carney Centre for Pharmacogenomics, University of Otago Christchurch, Christchurch Central City, New Zealand., Keltikangas-Järvinen L; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Hakulinen C; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Pulkki-Råback L; Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland., Havdahl A; Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway.; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway., Magnus P; Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway., Raitakari OT; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland., Perry JRB; MRC Epidemiology Unit, Institute of Metabolic Science, Cambridge Biomedical Campus, University of Cambridge School of Clinical Medicine, Cambridge, UK., Llop S; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain., Lopez-Espinosa MJ; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain.; Faculty of Nursing and Chiropody, Universitat de València, Valencia, Spain., Bønnelykke K; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Bisgaard H; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Sunyer J; ISGlobal, Barcelona Institute for Global Health, Barcelona, Spain.; Universitat Pompeu Fabra (UPF), Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland., Arseneault L; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., Standl M; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Heinrich J; Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University of Munich Medical Center, Ludwig-Maximilians-Universität München, Munich, Germany.; Allergy and Lung Health Unit, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Boden J; Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago Christchurch, Christchurch Central City, New Zealand., Pearson J; Biostatistics and Computational Biology Unit, Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch Central City, New Zealand., Horwood LJ; Christchurch Health and Development Study, Department of Psychological Medicine, University of Otago Christchurch, Christchurch Central City, New Zealand., Kennedy M; Department of Pathology and Biomedical Science, and Carney Centre for Pharmacogenomics, University of Otago Christchurch, Christchurch Central City, New Zealand., Poulton R; Dunedin Multidisciplinary Health and Development Research Unit, University of Otago, Dunedin, New Zealand., Eaves LJ; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human & Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA., Maes HH; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human & Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.; Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, USA., Hewitt J; Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, CO, USA.; Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA., Copeland WE; Department of Psychiatry, College of Medicine, University of Vermont, Burlington, VT, USA., Costello EJ; Department of Psychiatry, School of Medicine, Duke University, Durham, UK., Williams GM; School of Public Health, Faculty of Medicine, The University of Queensland, Herston, QLD, Australia., Wray N; Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia.; Queensland Brain Institute, Institute for Molecular Bioscience, University of Queensland, St Lucia, QLD, Australia., Järvelin MR; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., McGue M; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Iacono W; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Caspi A; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Moffitt TE; Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychology and Neuroscience and Center for Genomic and Computational Biology, Duke University, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA.; Social, Genetic, and Developmental Psychiatry Research Centre, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Whitehouse A; Telethon Kids Institute, The University of Western Australia, Perth, WA, Australia., Pennell CE; Faculty of Medicine and Health, School of Medicine and Public Health, The University of Newcastle, Callaghan, NSW, Australia., Klump KL; Department of Psychology, Michigan State University, East Lansing, MI, USA., Burt SA; Department of Psychology, Michigan State University, East Lansing, MI, USA., Dick DM; Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.; College Behavioral and Emotional Health Institute, Virginia Commonwealth University, Richmond, VA, USA., Reichborn-Kjennerud T; Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Martin NG; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Medland SE; QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia., Vrijkotte T; Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands., Kaprio J; Institute for Molecular Medicine FIMM, HiLife, University of Helsinki, Helsinki, Finland.; Department of Public Health, Medical Faculty, University of Helsinki, Helsinki, Finland., Tiemeier H; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Center, Rotterdam, The Netherlands.; Department of Social and Behavioral Science, Harvard TH Chan School of Public Health, Boston, MA, USA., Davey Smith G; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Hartman CA; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Oldehinkel AJ; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Casas M; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.; Department of Psychiatry and Legal Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain., Ribasés M; Department of Psychiatry, Hospital Universitari Vall d'Hebron, Barcelona, Spain.; Biomedical Network Research Centre on Mental Health (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.; Psychiatric Genetics Unit, Group of Psychiatry, Mental Health and Addiction, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain., Lichtenstein P; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden., Lundström S; Gillberg Neuropsychiatry Centre, University of Gothenburg, Gothenburg, Sweden.; Centre for Ethics, Law and Mental Health, University of Gothenburg, Gothenburg, Sweden., Plomin R; Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK., Bartels M; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.bartels@vu.nl.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. m.bartels@vu.nl., Nivard MG; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. m.g.nivard@vu.nl., Boomsma DI; Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. di.boomsma@vu.nl.; Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. di.boomsma@vu.nl. |
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| Jazyk: | angličtina |
| Zdroj: | Translational psychiatry [Transl Psychiatry] 2021 Jul 30; Vol. 11 (1), pp. 413. Date of Electronic Publication: 2021 Jul 30. |
| DOI: | 10.1038/s41398-021-01480-x |
| Abstrakt: | Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association meta-analysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis (AGG (© 2021. The Author(s).) |
| Databáze: | MEDLINE |
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