Adherence to Medication among Patients with Chronic Hepatitis B Infection Attending a Tertiary Hospital in South Western Nigeria.

Autor:	Akande KO; Department of Medicine, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria., Faneye AO; Department of Virology, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria., Olusola BA; Department of Virology, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria., Otegbayo JA; Department of Medicine, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria., Arije A; Department of Medicine, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria., Olaleye DO; Department of Virology, College of Medicine, University of Ibadan, Oyo State, Ibadan, Nigeria.
Jazyk:	angličtina
Zdroj:	West African journal of medicine [West Afr J Med] 2021 Jul 29; Vol. 38 (7), pp. 629-633.
Abstrakt:	Introduction: Chronic hepatitis B (CHB) is an international public health problem. Treatment reduces its morbidity, mortality and infectivity. The aim of this study was to determine adherence among CHB infected patients on Tenofovir and the reasons for non-adherence. Methodology: It was a cross-sectional study of patients on tenofovir for at least 6 months. Information was obtained on bio- data, adherence to tenofovir, duration and reasons for nonadherence using an interviewer administered questionnaire. Non- adherence was defined as patient reporting missing medication at all. Chi square or Fisher exact test and Student's t-test were used to determine associations. P value less than 0.05 was considered significant. Results: A total of 150 participants comprising of 76 (50.7%) females and 74 (49.3%) males with mean age of 39.2 ± 11.4 years, participated in the study. Non adherence rate was 65%. There was no significant association between non-adherence and tribe (p=0.7), level of education (p=0.8), religion (p=0.2), sex (p=0.9), clinical state (p=0.8), treatment experience (p=0.8) and months on Tenofovir (0.1) while a significant association existed with age (0.01), the presence of comorbidity (p=0.02) and taking another medication apart from tenfovir (0.00). The reasons for non-adherence included out of station 22 (14.7%), financial constraint 19(12.5%), unavailability of the drug 19 (12.5%), forgetfulness 15 (10%), perceived side effects 12 (8%), undetectable serum DNA quantification 11 (7.3%), ignorance of continuous use of Tenofovir 10 (6.7%), and pregnancy 9 (6%) among others. Conclusion: Adherence to Tenofovir is poor among CHB patients attending University College Hospital, Ibadan. Competing Interests: The authors certifies that there is no conflict of interest in connection with the submitted article. (Copyright © 2021 by West African Journal of Medicine.)
Databáze:	MEDLINE
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