Previous exposure to dengue virus is associated with increased Zika virus burden at the maternal-fetal interface in rhesus macaques.

Autor:	Crooks CM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Weiler AM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Rybarczyk SL; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Bliss MI; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Jaeger AS; Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, St. Paul, Minnesota, United States of America., Murphy ME; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Simmons HA; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Mejia A; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Fritsch MK; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Hayes JM; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Eickhoff JC; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Mitzey AM; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Razo E; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Braun KM; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Brown EA; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Yamamoto K; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Shepherd PM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Possell A; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Weaver K; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Antony KM; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Morgan TK; Department of Pathology, Oregon Health and Science University, Portland, Oregon, United States of America.; Department of Obstetrics and Gynecology, Oregon Health and Science University, Portland, Oregon, United States of America., Newman CM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Dudley DM; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Schultz-Darken N; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Peterson E; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Katzelnick LC; Division of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, California, United States of America., Balmaseda A; Sustainable Sciences Institute, Managua, Nicaragua., Harris E; Division of Infectious Diseases and Vaccinology, University of California Berkeley, Berkeley, California, United States of America., O'Connor DH; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Mohr EL; Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Golos TG; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Department of Obstetrics and Gynecology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Friedrich TC; Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.; Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, United States of America., Aliota MT; Department of Veterinary and Biomedical Sciences, University of Minnesota, Twin Cities, St. Paul, Minnesota, United States of America.
Jazyk:	angličtina
Zdroj:	PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Jul 30; Vol. 15 (7), pp. e0009641. Date of Electronic Publication: 2021 Jul 30 (Print Publication: 2021).
DOI:	10.1371/journal.pntd.0009641
Abstrakt:	Concerns have arisen that pre-existing immunity to dengue virus (DENV) could enhance Zika virus (ZIKV) disease, due to the homology between ZIKV and DENV and the observation of antibody-dependent enhancement (ADE) among DENV serotypes. To date, no study has examined the impact of pre-existing DENV immunity on ZIKV pathogenesis during pregnancy in a translational non-human primate model. Here we show that macaques with a prior DENV-2 exposure had a higher burden of ZIKV vRNA in maternal-fetal interface tissues as compared to DENV-naive macaques. However, pre-existing DENV immunity had no detectable impact on ZIKV replication kinetics in maternal plasma, and all pregnancies progressed to term without adverse outcomes or gross fetal abnormalities detectable at delivery. Understanding the risks of ADE to pregnant women worldwide is critical as vaccines against DENV and ZIKV are developed and licensed and as DENV and ZIKV continue to circulate. Competing Interests: The authors have declared that no competing interests exist.
Databáze:	MEDLINE
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