Psychiatric disorders in individuals with neurofibromatosis 1 in Denmark: A nationwide register-based cohort study.

Autor: Kenborg L; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Andersen EW; Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark., Duun-Henriksen AK; Statistics and Data Analysis, Danish Cancer Society Research Center, Copenhagen, Denmark., Jepsen JRM; Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research and Center for Neuropsychiatric Schizophrenia Research, Mental Health Service Capital Region, University of Copenhagen, Copenhagen, Denmark.; Child and Adolescent Mental Health Centre, Mental Health Services Capital Region, University of Copenhagen, Copenhagen, Denmark., Doser K; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Dalton SO; Survivorship and Inequality in Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Clinical Oncology and Palliative Care, Zealand University Hospital, Naestved, Denmark., Bidstrup PE; Psychological Aspects of Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark., Krøyer A; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Frederiksen LE; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark., Johansen C; Psychological Aspects of Cancer, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Oncology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Østergaard JR; Department of Pediatrics, Centre for Rare Diseases, Aarhus University Hospital, Aarhus, Denmark., Hove H; Department of Pediatrics, Centre for Rare Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.; The RareDis Database, Section of Rare Diseases, Department of Clinical Genetics and Pediatrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark., Sørensen SA; Department of Neurogenetics, Institute of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark., Riccardi VM; The Neurofibromatosis Institute, La Crescenta, California, USA., Mulvihill JJ; Department of Pediatrics, University of Oklahoma, Oklahoma City, Oklahoma, USA., Winther JF; Childhood Cancer Research Group, Danish Cancer Society Research Center, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health, Aarhus University and University Hospital, Aarhus, Denmark.
Jazyk: angličtina
Zdroj: American journal of medical genetics. Part A [Am J Med Genet A] 2021 Dec; Vol. 185 (12), pp. 3706-3716. Date of Electronic Publication: 2021 Jul 29.
DOI: 10.1002/ajmg.a.62436
Abstrakt: The aim of this study was to assess the risks of psychiatric disorders in a large cohort of 905 individuals with NF1 and 7614 population comparisons matched on sex and year of birth. The cohort was linked to the Danish Psychiatric Central Research Register to ascertain information on hospital contacts for psychiatric disorders based on the International Classification of Diseases version 8 and 10. The hazard ratio (HR) for a first psychiatric hospital contact was higher in girls (4.19, 95% confidence interval [CI] 1.81-9.69) and boys with NF1 (5.02, 95% CI 3.27-7.69) <7 years of age than in the population comparisons. Both sexes had increased HRs for developmental disorders, including attention deficit/hyperactivity disorders, autism spectrum disorders, and intellectual disabilities in childhood. Females with NF1 had also increased HRs for unipolar depression, other emotional and behavioral disorders, and severe stress reaction and adjustment disorders in early adulthood. The HRs for psychoses, schizophrenia, bipolar disorders, and substance abuse were similar in individuals with NF1 and the population comparisons. Finally, the cumulative incidence of a first hospital contact due to any psychiatric disorder by age 30 years was 35% (95% CI 29-41) in females and 28% (95% CI 19-37) in males with NF1. Thus, screening for psychiatric disorders may be important for early diagnosis and facilitation of appropriate and effective treatment in individuals with NF1.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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