Endogenous control of inflammation characterizes pregnant women with asymptomatic or paucisymptomatic SARS-CoV-2 infection.

Autor: De Biasi S; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Tartaro DL; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Gibellini L; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Paolini A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Quong A; Fluidigm Corporation, South San Francisco, CA, USA., Petes C; Fluidigm Corporation, South San Francisco, CA, USA., Awong G; Fluidigm Corporation, South San Francisco, CA, USA., Douglas S; Fluidigm Corporation, South San Francisco, CA, USA., Lin D; Fluidigm Corporation, South San Francisco, CA, USA., Nieto J; Fluidigm Corporation, South San Francisco, CA, USA., Galassi FM; College of Humanities, Arts and Social Sciences, Flinders University, Bedford Park, SA, 5042, Australia., Borella R; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Fidanza L; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Mattioli M; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Leone C; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Neri I; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Meschiari M; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy., Cicchetti L; Labospace, Milano, Italy., Iannone A; Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Trenti T; Department of Clinical Pathology, AOU Policlinico, Modena, Italy., Sarti M; Department of Clinical Pathology, AOU Policlinico, Modena, Italy., Girardis M; Department of Anesthesia and Intensive Care, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy., Guaraldi G; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy., Mussini C; Infectious Diseases Clinics, AOU Policlinico and University of Modena and Reggio Emilia, Modena, Italy., Facchinetti F; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy., Cossarizza A; Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia School of Medicine, Modena, Italy. andrea.cossarizza@unimore.it.; National Institute for Cardiovascular Research, Bologna, Italy. andrea.cossarizza@unimore.it.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2021 Jul 29; Vol. 12 (1), pp. 4677. Date of Electronic Publication: 2021 Jul 29.
DOI: 10.1038/s41467-021-24940-w
Abstrakt: SARS-CoV-2 infection can affect all human beings, including pregnant women. Thus, understanding the immunological changes induced by the virus during pregnancy is nowadays of pivotal importance. Here, using peripheral blood from 14 pregnant women with asymptomatic or mild SARS-CoV-2 infection, we investigate cell proliferation and cytokine production, measure plasma levels of 62 cytokines, and perform a 38-parameter mass cytometry analysis. Our results show an increase in low density neutrophils but no lymphopenia or gross alterations of white blood cells, which display normal levels of differentiation, activation or exhaustion markers and show well preserved functionality. Meanwhile, the plasma levels of anti-inflammatory cytokines such as interleukin (IL)-1RA, IL-10 and IL-19 are increased, those of IL-17, PD-L1 and D-dimer are decreased, but IL-6 and other inflammatory molecules remain unchanged. Our profiling of antiviral immune responses may thus help develop therapeutic strategies to avoid virus-induced damages during pregnancy.
(© 2021. The Author(s).)
Databáze: MEDLINE
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