Asystolic cardiac arrest following liposomal amphotericin B infusion: anaphylaxis or compliment activation-related pseudoallergy?

Autor: Drewett GP; Department of Infectious Diseases, Austin Health, Heidelberg, Australia. george.drewett@austin.org.au.; Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia. george.drewett@austin.org.au., Copaescu A; Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.; Department of Clinical Immunology and Allergy, McGill University Health Centre, Montréal, Canada., DeLuca J; Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Australia., Holmes NE; Department of Infectious Diseases, Austin Health, Heidelberg, Australia.; Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.; Data Analytics Research and Evaluation (DARE) Centre, Austin Health and University of Melbourne, Heidelberg, Australia., Trubiano JA; Department of Infectious Diseases, Austin Health, Heidelberg, Australia.; Department of Drug and Antibiotic Allergy Services, Austin Health, Heidelberg, Australia.; Department of Medicine (Austin Health), University of Melbourne, Heidelberg, Australia.
Jazyk: angličtina
Zdroj: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology [Allergy Asthma Clin Immunol] 2021 Jul 29; Vol. 17 (1), pp. 80. Date of Electronic Publication: 2021 Jul 29.
DOI: 10.1186/s13223-021-00582-x
Abstrakt: Allergic reaction to liposomal amphotericin B is rare. We report a case of cardiac arrest in a 64-year-old woman following liposomal amphotericin B infusion, requiring resuscitation. We also present the results of subsequent skin prick and intradermal testing to liposomal amphotericin on the patient and three healthy controls, highlighting the need for further research into the immunopathogenesis of this reaction.
(© 2021. The Author(s).)
Databáze: MEDLINE
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