Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression.

Autor: Khadrawy YA; Medical Physiology Department, Medical Division, National Research Centre, Giza, Egypt. Electronic address: Ym.khadrawy@nrc.sci.eg., Hosny EN; Medical Physiology Department, Medical Division, National Research Centre, Giza, Egypt., Magdy M; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt., Mohammed HS; Biophysics Department, Faculty of Science, Cairo University, Giza, Egypt.
Jazyk: angličtina
Zdroj: European journal of pharmacology [Eur J Pharmacol] 2021 Oct 05; Vol. 908, pp. 174384. Date of Electronic Publication: 2021 Jul 27.
DOI: 10.1016/j.ejphar.2021.174384
Abstrakt: The antidepressant effect of curcumin-coated iron oxide nanoparticles (Cur-IONPs) was investigated in the current study using depression rat model induced by reserpine. IONPs were synthesized by curcumin as a reducing agent producing Cur-IONPs. Rats were divided into control, depression rat model, and depressed rats treated with Cur-IONPs. After treatment rat behavior was evaluated using forced swimming test (FST). Serotonin (5-HT), norepinephrine (NE), dopamine (DA), monoamine oxidase (MAO), acetylcholinesterase (AchE), Na + , K + , ATPase, lipid peroxidation (MDA), reduced glutathione (GSH), glutathione-s-transferase (GST) and nitric oxide (NO) were measured in the cortex and hippocampus. In depressed rats, FST showed increased immobilization time and reduced swimming time. This was associated with a significant decrease in 5-HT, NE, DA and GSH and a significant increase in MDA and NO levels and GST, MAO, AchE and Na + , K + , ATPase activities in the cortex and hippocampus. Treatment with Cur-NONPs for two weeks increased the swimming time reduced the immobility time, and elevated 5-HT, NE and DA levels. Cur-IONPs attenuated the oxidative stress induced by reserpine and restored the MAO, AchE and Na + , K + , ATPase. The present green method used curcumin in the IONPs synthesis and has several merits; obtaining nanoform of iron oxide, increasing the bioavailability of curcumin and reducing the oxidative stress induced by iron. The present antidepressant effect of Cur-IONPs could be attributed to the ability of Cur-IONPs to restore monoamine neurotransmitter levels by increasing their synthesis and reducing their metabolism. In addition, the antioxidant activity of curcumin prevented oxidative stress in the depressed rats.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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