The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock.

Autor:	Brooks JF 2nd; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Behrendt CL; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Ruhn KA; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lee S; Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Raj P; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Takahashi JS; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Hooper LV; Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; The Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: lora.hooper@utsouthwestern.edu.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2021 Aug 05; Vol. 184 (16), pp. 4154-4167.e12. Date of Electronic Publication: 2021 Jul 28.
DOI:	10.1016/j.cell.2021.07.001
Abstrakt:	Environmental light cycles entrain circadian feeding behaviors in animals that produce rhythms in exposure to foodborne bacteria. Here, we show that the intestinal microbiota generates diurnal rhythms in innate immunity that synchronize with feeding rhythms to anticipate microbial exposure. Rhythmic expression of antimicrobial proteins was driven by daily rhythms in epithelial attachment by segmented filamentous bacteria (SFB), members of the mouse intestinal microbiota. Rhythmic SFB attachment was driven by the circadian clock through control of feeding rhythms. Mechanistically, rhythmic SFB attachment activated an immunological circuit involving group 3 innate lymphoid cells. This circuit triggered oscillations in epithelial STAT3 expression and activation that produced rhythmic antimicrobial protein expression and caused resistance to Salmonella Typhimurium infection to vary across the day-night cycle. Thus, host feeding rhythms synchronize with the microbiota to promote rhythms in intestinal innate immunity that anticipate exogenous microbial exposure. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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