Human herpesvirus 6 and epilepsy.

Autor: Theodore WH; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Leibovitch E; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Billioux BJ; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Inati SK; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Zaghloul K; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Heiss J; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA., Gaillard WD; Department of Neurology, Children's National Medical Center, Washington, DC, USA., Jacobson S; Division of Intramural Research, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Jazyk: angličtina
Zdroj: Epilepsia open [Epilepsia Open] 2021 Dec; Vol. 6 (4), pp. 777-780. Date of Electronic Publication: 2021 Aug 08.
DOI: 10.1002/epi4.12531
Abstrakt: We investigated the association between human herpesvirus 6 (HHV-6) and mesial temporal sclerosis (MTS) in 87 patients who had surgery for drug-resistant epilepsy. Fifty-four had MTS, 22 focal cortical dysplasia (FCD), four tumors, three vascular malformations, and three a history of encephalitis. We extracted DNA from fresh brain tissue immediately after surgery and performed viral detection with quantitative real-time polymerase chain reaction (PCR) or digital droplet PCR specific for HHV-6A and HHV-6B. Tissue was studied with standard clinical techniques, including hematoxylin and eosin, glial fibrillary acidic protein, and NeuN stains. Twenty-nine of 54 patients with MTS, six of 23 with focal cortical dysplasia (FCD), and one of three with a history of encephalitis were positive for HHV-6 (P < .02). Febrile seizure history was not associated with HHV-6 detection. Patients with MTS had significantly lower seizure onset age than those with other pathologies. Thirteen patients had positron emission tomography with [11C]PBR28, a marker for reactive astrocytes and activated microglia; there was a trend for HHV-6-positive patients to have higher binding in their seizure foci, suggesting inflammation. Our study supports a potential role for HHV-6 in the etiology of MTS.
(Published 2021. This article is a U.S. Government work and is in the public domain in the USA. Epilepsia Open published by Wiley Periodicals LLC on behalf of International League Against Epilepsy.)
Databáze: MEDLINE
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