Vaginal estrogen and association with dementia: A nationwide population-based study.
| Autor: | Pourhadi N; Memory Clinic, Department of Neurology, Rigshospitalet, Copenhagen, Denmark., Mørch LS; Cancer Surveillance and Pharmacoepidemiology, Danish Cancer Society Research Center, Copenhagen, Denmark., Holm EA; Department of Medicine, Zealand University Hospital, Køge, Denmark.; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark., Torp-Pedersen CT; Department of Cardiology, Nordsjaellands Hospital, Hillerød, Denmark.; Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Meaidi A; Department of Gynaecology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2022 Apr; Vol. 18 (4), pp. 625-634. Date of Electronic Publication: 2021 Jul 28. |
| DOI: | 10.1002/alz.12417 |
| Abstrakt: | Introduction: Use of systemic hormone therapy has been positively associated with development of dementia. Little is known about the dose-dependent effect of vaginal estradiol on dementia risk. Methods: We assessed associations between cumulative dose of vaginal estradiol tablets and dementia in a case-control study nested in a nationwide Danish cohort of women aged 50 to 60 years at study initiation, who did not use systemic hormone therapy. Each case was age-matched to 10 female controls. Results: A total of 4574 dementia cases were matched to 45,740 controls. Cumulative use of vaginal estradiol tablets was not associated with all-cause dementia; adjusted hazard ratio 1.02 (95% confidence interval [CI] 0.89-1.18) for low dose (< 750 mcg), 1.07 (0.94-1.21) for medium dose (750-2000 mcg), and 0.93 (0.84-1.03) for high dose (> 2000 mcg). Similarly, Alzheimer's disease (AD) only was not associated with vaginal estradiol. Discussion: Exposure to vaginal estradiol tablets was not associated with all-cause dementia or AD only. (© 2021 the Alzheimer's Association.) |
| Databáze: | MEDLINE |
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