Peripartum cardiomyopathy: from genetics to management.
| Autor: | Sliwa K; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, South Africa.; Department of Medicine, Division of Cardiology, Groote Schuur Hospital, University of Cape Town, South Africa., Bauersachs J; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Arany Z; Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA, USA., Spracklen TF; Cape Heart Institute, Faculty of Health Sciences, University of Cape Town, South Africa., Hilfiker-Kleiner D; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.; Medical Faculty of the Philipps University Marburg, Marburg, Germany. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | European heart journal [Eur Heart J] 2021 Aug 21; Vol. 42 (32), pp. 3094-3102. |
| DOI: | 10.1093/eurheartj/ehab458 |
| Abstrakt: | Peripartum cardiomyopathy (PPCM) is a disease that occurs globally in all ethnic groups and should be suspected in any peripartum women presenting with symptoms and signs of heart failure, towards the end of pregnancy or in the months following delivery, with confirmed left ventricular dysfunction. After good history taking, all women should be thoroughly assessed, and alternative causes should be excluded. Urgent cardiac investigations with electrocardiogram and natriuretic peptide measurement (if available) should be performed. Echocardiography follows as the next step in investigation. Patients with abnormal cardiac investigations should be urgently referred to a cardiology team for expert management. Referral for genetic work-up should be considered if there is a family history of cardiomyopathy or sudden death. PPCM is a disease with substantial maternal and neonatal morbidity and mortality. Maternal mortality rates range widely, from 0% to 30%, depending on the ethnic background and geographic region. Just under half of women experience myocardial recovery. Remarkable advances in the comprehension of the pathogenesis and in patient management and therapy have been achieved, largely due to team efforts and close collaboration between basic scientists, cardiologists, intensive care specialists, and obstetricians. This review summarizes current knowledge of PPCM genetics, pathophysiology, diagnostic approach, management, and outcome. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|