Characteristics, management and outcomes of critically ill COVID-19 patients admitted to ICU in hospitals in Bangladesh: a retrospective study.

Autor:	Saha A; Disease Biology and Molecular Epidemiology Research Group, Chattogram, Bangladesh.; Children's Cancer Institute, Faculty of Medicine, University of New South Wales, Australia., Ahsan MM; Intensive Care Unit, 250 Beded General Hospital, Chattogram, Bangladesh., Quader TU; Intensive Care Unit, Chittagong Medical College, Chattogram, Bangladesh., Shohan MUS; Department of Biochemistry and Molecular Biology, University of Dhaka, Dhaka, Bangladesh., Naher S; Department of Microbiology, University of Chittagong, Chattogram, Bangladesh., Dutta P; Disease Biology and Molecular Epidemiology Research Group, Chattogram, Bangladesh.; Department of Pharmacy, BGC Trust University Bangladesh, Chattogram, Bangladesh., Akash AS; Department of Genetic Engineering and Biotechnology, University of Chittagong, Chattogram, Bangladesh., Mehedi HMH; Department of Medicine, 250 Beded General Hospital, Bangladesh., Chowdhury AAU; Intensive Care Unit, 250 Beded General Hospital, Chattogram, Bangladesh., Karim H; Intensive Care Unit, 250 Beded General Hospital, Chattogram, Bangladesh., Rahman T; Department of Microbiology and Virology, Chittagong Medical College, Chattogram, Bangladesh., Parvin A; Department of Biochemistry, Chittagong Medical College, Chattogram, Bangladesh.
Jazyk:	angličtina
Zdroj:	Journal of preventive medicine and hygiene [J Prev Med Hyg] 2021 Apr 29; Vol. 62 (1), pp. E33-E45. Date of Electronic Publication: 2021 Apr 29 (Print Publication: 2021).
DOI:	10.15167/2421-4248/jpmh2021.62.1.1838
Abstrakt:	Objectives: This study aimed to analyze the epidemiological and clinical characteristics of COVID-19 cases and investigate risk factors including comorbidities and age in relation with the clinical aftermath of COVID-19 in ICU admitted cases in Bangladesh. Methods: In this retrospective study, epidemiological and clinical characteristics, complications, laboratory results, and clinical management of the patients were studied from data obtained from 168 individuals diagnosed with an advanced prognosis of COVID-19 admitted in two hospitals in Bangladesh. Results: Individuals in the study sample contracted COVID-19 through community transmission. 56.5% (n = 95) cases died in intensive care units (ICU) during the study period. The median age was 56 years and 79.2% (n = 134) were male. Typical clinical manifestation included Acute respiratory distress syndrome (ARDS) related complications (79.2%), fever (54.2%) and cough (25.6%) while diabetes mellitus (52.4%), hypertension (41.1%) and heart diseases (16.7%) were the conventional comorbidities. Clinical outcomes were detrimental due to comorbidities rather than age and comorbid individuals over 50 were at more risk. In the sample, oxygen saturation was low (< 95% SpO2) in 135 patients (80.4%) and 158 (93.4%) patients received supplemental oxygen. Identical biochemical parameters were found in both deceased and surviving cases. Administration of antiviral drug Remdesivir and the glucocorticoid, Dexamethasone increased the proportion of surviving patients slightly. Conclusions: Susceptibility to developing critical illness due to COVID-19 was found more in comorbid males. These atypical patients require more clinical attention from the prospect of controlling mortality rate in Bangladesh. Competing Interests: Conflicts of interest statement The authors declare no conflict of interest. (©2021 Pacini Editore SRL, Pisa, Italy.)
Databáze:	MEDLINE
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