Incidence of lupus anticoagulant in hospitalized covid-19 patients.

Autor:	Owaidah T; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA.; Alfaisal University Riyadh 11533, KSA., Saleh M; Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA., Aguilos AM; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA., Amri AA; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA., Maghrabi K; Department of Critical Care, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA., Owaidah M; Alfaisal University Riyadh 11533, KSA., Siddiqui K; Department of Pediatric Hematology Oncology, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA., Alsaleh K; Department of Medicine, College of Medicine, King Saud University Riyadh 12372, KSA., Alnounou R; Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Centre Riyadh 11211, KSA.
Jazyk:	angličtina
Zdroj:	American journal of blood research [Am J Blood Res] 2021 Jun 15; Vol. 11 (3), pp. 317-324. Date of Electronic Publication: 2021 Jun 15 (Print Publication: 2021).
Abstrakt:	Background: Procoagulant profile of 2019-nCoV/SARS-CoV-2 has been well documented over the last year. Perturbance in coagulating factors has also been reported in Covid-19 patients, including increased d-dimers and reports of lupus anticoagulant (LA). Methods: The current study aimed to identify the incidence of positivity of lupus anticoagulant in Covid-19 patients and analyze the association between LA and D-dimer in predicting thrombosis and mortality in one-hundred and five hospitalized adult (age >14 years) patients and forty-three hospitalized pediatric (age <14 years) patients with a confirmed diagnosis of Covid-19 between June 2020 and September 2020. Results: Twenty-one (20%) adult patients were tested positive for PTT LA, of which nine (8.6%) turned out to be confirmed positive for LA through StaClot and DRVVT Ratio tests. Six (14%) pediatric patients were positive for PTT LA, and only one (2.3%) had positive StaClot. Median D-dimer at admission was positively correlated with age and CRP among adult patients and was significantly higher in expired cases (P=0.001). No association between any of the coagulation tests and thrombosis or mortality was observed in the pediatric cohort. Conclusion: We report an increased incidence of LA in Covid-19 patients, yet we didn't find any association between thrombotic events or mortality, probably due to the small sample size. Competing Interests: None. (AJBR Copyright © 2021.)
Databáze:	MEDLINE
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