Non-CpG methylation-a key epigenetic modification in cancer.
| Autor: | Ramasamy D, Deva Magendhra Rao AK, Rajkumar T, Mani S |
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| Jazyk: | angličtina |
| Zdroj: | Briefings in functional genomics [Brief Funct Genomics] 2021 Sep 11; Vol. 20 (5), pp. 304-311. |
| DOI: | 10.1093/bfgp/elab035 |
| Abstrakt: | The methylation of cytosine residues that precede adenine/thymine or other cytosine nucleotides instead of guanine in DNA is known as non-CpG methylation. It is a pronounced epigenetic modification with a central role in gene regulation similar to CpG methylation. Due to technological limitations, the locus-specific role of non-CpG methylation was scarcely understood. At present, high-throughput analyses and improved enrichment methods can elucidate the role of genome-wide non-CpG methylation distributions. Although the functional basis of non-CpG methylation in regulating gene expression control is known, its role in cancer development is yet to be ascertained. This review sheds light on the possible mechanism of non-CpG methylation in embryos and developed tissues with a special focus on cancer development and progression. In particular, the maintenance and alteration of non-CpG methylation levels and the crucial factors that determine this level of non-CpG methylation and its functional role in cancer are discussed. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
| Databáze: | MEDLINE |
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