Impact of endoscopic submucosal dissection and epithelial cell sheet engraftment on systemic cytokine dynamics in patients with oesophageal cancer.

Autor: Yoshida A; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504, Japan., Takata T; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504, Japan. t-takata@tottori-u.ac.jp., Kanda T; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504, Japan.; Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Yamaguchi N; Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Minami H; Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Nakao K; Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, 852-8501, Japan., Kobayashi S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan., Eguchi S; Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, 852-8501, Japan., Isomoto H; Division of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago, Tottori, 683-8504, Japan.; Department of Gastroenterology and Hepatology, Nagasaki University Hospital, Nagasaki, 852-8501, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Jul 27; Vol. 11 (1), pp. 15282. Date of Electronic Publication: 2021 Jul 27.
DOI: 10.1038/s41598-021-94871-5
Abstrakt: The tumour microenvironment (TME) plays an important role in cancer development, progression, and metastasis. Various cytokines are present in the TME in oesophageal cancer. Oesophageal stricture is a major complication of endoscopic submucosal dissection (ESD) for oesophageal cancer, and inflammatory cytokines are closely related to its pathogenesis. However, the cytokine crosstalk involved in the oesophageal cancer TME and post-ESD stricture has not been fully elucidated. This study investigated the comprehensive cytokine dynamics following ESD in patients with oesophageal cancer. In addition, the effect of a novel preventive technique for post-ESD stricture, autologous cell sheet engraftment, on cytokine levels was evaluated. Various pro-inflammatory and anti-tumorigenic cytokines were elevated in patients with oesophageal cancer, and ESD transiently influenced cytokine concentrations. IL-1β and TNF-α, two major pro-inflammatory cytokines that induce oesophageal stricture, were significantly suppressed by cell sheet engraftment. In conclusion, this study revealed the distinct cytokine dynamics after ESD in patients with oesophageal cancer, together with the effect of autologous cell sheet engraftment on cytokine fluctuation. These results can accelerate research on the TME and therapeutic strategies for oesophageal cancer.
(© 2021. The Author(s).)
Databáze: MEDLINE
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