Impact of Increased Hemoglobin on Spontaneous Intracerebral Hemorrhage.

Autor: Lu Y; Department of Neurology, Peking University First Hospital, Beijing, China., Jin H; Department of Neurology, Peking University First Hospital, Beijing, China., Zhao Y; Department of Neurology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China., Li Y; Department of Neurology, Peking University First Hospital, Beijing, China., Xu J; Department of Cognitive Neurology, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China., Tian J; Department of Neurology, Peking University First Hospital, Beijing, China., Luan X; Department of Neurology, The First Hospital of Tsinghua University, Beijing, China., Chen S; Department of Neurology, Peking University First Hospital, Beijing, China., Sun W; Department of Neurology, Peking University First Hospital, Beijing, China., Zhang S; Department of Psychiatry, Beijing Geriatric Hospital, Beijing, China., Xu S; Department of Neurology, the Second Hospital, Shandong University, Jinan, Shandong Province, China., Zhu F; Cognitive Impairment Ward of Neurology Department, the Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, China., Chen L; Department of Ultrasound, Peking University First Hospital, Beijing, China., Mima D; Department of Neurology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China., Sun Y; Department of Neurology, Peking University First Hospital, Beijing, China. sya75@163.com., Zhuoga C; Department of Neurology, People's Hospital of Tibet Autonomous Region, Lhasa, Tibet, China. 18008995160@163.com.
Jazyk: angličtina
Zdroj: Neurocritical care [Neurocrit Care] 2022 Apr; Vol. 36 (2), pp. 395-403. Date of Electronic Publication: 2021 Jul 27.
DOI: 10.1007/s12028-021-01305-1
Abstrakt: Background: Studies of the impact of increased hemoglobin on spontaneous intracerebral hemorrhage (ICH) are limited. The present study aimed to explore the effect of increased hemoglobin on ICH.
Methods: A retrospective single-center study using medical records from a database processed by univariate and multivariate analyses was performed in the People's Hospital of Tibet Autonomous Region in Lhasa, Tibet, China.
Results: The mean hemoglobin level in 211 patients with ICH was 165.03 ± 34.12 g/l, and a median hematoma volume was 18.5 ml. Eighty-eight (41.7%) patients had large hematomas (supratentorial hematoma ≥ 30 ml; infratentorial hematoma ≥ 10 ml). No differences in ICH risk factors between the groups with different hemoglobin levels were detected. Increased hemoglobin was independently associated with large hematomas [odds ratio (OR) 1.013, P = 0.023]. Increased hemoglobin was independently associated with ICH with subarachnoid hemorrhage (OR 1.014, P = 0.016), which was more pronounced in men (OR 1.027, P = 0.002). Increased hemoglobin was independently associated with basal ganglia hemorrhage and lobar hemorrhage in men (OR 0.986, P = 0.022; OR 1.013, P = 0.044, respectively) but not in women (P > 0.1).
Conclusions: Increased hemoglobin was independently associated with large hemorrhage volume. Increased hemoglobin was independently associated with lobar hemorrhage in men and ICH with subarachnoid hemorrhage, which was more pronounced in men. Additional studies are needed to confirm our findings and explore potential mechanisms.
(© 2021. The Author(s).)
Databáze: MEDLINE
Externí odkaz: