Histopathological and molecular profiling of lung adenocarcinoma skin metastases reveals specific features.

Autor: Forest F; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France.; University Hospital of Saint Etienne, Saint Etienne, France.; Corneal Graft Biology, Engineering and Imaging Laboratory, Federative Institute of Research in Sciences and Health Engineering, Jean Monnet University, Saint-Etienne, France., Laville D; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France., Habougit C; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France., Da Cruz V; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France., Casteillo F; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France., Yvorel V; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France.; University Hospital of Saint Etienne, Saint Etienne, France., Bard-Sorel S; Technopole Pathologie, Saint-Étienne, France., Godard W; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France.; Institut de Pathologie du Forez, Saint-Étienne, France., Picot T; University Hospital of Saint Etienne, Saint Etienne, France., Tiffet O; Department of Thoracic Surgery, University Hospital of Saint Etienne, Saint Etienne, France., Perrot JL; Department of Dermatology, University Hospital of Saint Etienne, Saint Etienne, France., Péoc'h M; Department of Pathology, University Hospital of Saint Etienne, Saint Etienne, France.
Jazyk: angličtina
Zdroj: Histopathology [Histopathology] 2021 Dec; Vol. 79 (6), pp. 1051-1060. Date of Electronic Publication: 2021 Sep 12.
DOI: 10.1111/his.14463
Abstrakt: Aims: Little is known regarding the histopathological and molecular features of lung adenocarcinoma skin metastases. Our study is the largest, to our knowledge, to comprehensively explore these to date.
Methods and Results: We performed a retrospective cohort study analysing 42 lung adenocarcinoma skin metastasis samples obtained from a database of 2659 lung adenocarcinomas collected between 2010 and 2020. EGFR exon 19 deletion was detected in one patient and KRAS mutations were detected in 12 (33.3%) patients. The programmed cell death ligand 1 (PD-L1) tumour proportion score was <1% in 27 patients, ≥1% and <50% in eight patients, ≥50% in six patients and not assessable in one patient. We showed that the predominant histopathological subtype is different from that at other metastatic sites (P = 0.024). Thyroid transcription factor I (TTF-1) was more often negative in skin metastases compared to other sites (P < 0.001). The EGFR mutation rate tended to be lower for skin metastases compared to other sites (P = 0.079). Skin metastases were associated with a high rate of PD-L1-negative cases (P = 0.022).
Conclusion: Our work shows that the skin metastases of lung adenocarcinoma have a specific histopathological profile.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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