| Autor: |
Altmann P; Department of Nephrology, London Hospital, United Kingdom., Butter KC, Plowman D, Chaput de Saintonge DM, Cunningham J, Marsh FP |
| Jazyk: |
angličtina |
| Zdroj: |
Kidney international [Kidney Int] 1987 Nov; Vol. 32 (5), pp. 710-3. |
| DOI: |
10.1038/ki.1987.264 |
| Abstrakt: |
We investigated 106 home hemodialysis patients whose mean [+/- SEM] serum aluminum (Al) concentration was 60.9 +/- 4.1 micrograms/liter. Serum Al concentration was inversely related to daily urine output (r = -0.52, P less than 0.001). Urine volume and measurements of Al exposure were included in a multivariate analysis of serum Al concentration in the 62 patients whose urine output was greater than 10 ml/day. The multiple correlation coefficient (r) was 0.70 (P less than 0.001) and the percentage contributions to r2 (indicating the relative importance of each factor) were: urine output 57%, oral Al intake 36%, total dialysis hours 7%. The additional contribution from cumulative water Al was negligible. In a subgroup of 26 patients with a urine output exceeding 10 ml/day, urinary Al excretion averaged 15.4 micrograms/day, and renal Al clearance and serum Al concentration were inversely related (r = -0.69, P less than 0.001). We conclude that Al-containing phosphate binders were a more important source of Al than was dialysate in these patients and that residual renal function can reduce the severity of hyperaluminemia in hemodialysis patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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