| Autor: |
Alm Rosenblad M; Department of Chemistry and Molecular Biology, National Infrastructure of Bioinformatics (NBIS), Lundberg Laboratory, University of Gothenburg, Gothenburg, Sweden., López MD; Bioinformatics Core Facility, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Samuelsson T; Department of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, Sweden. |
| Jazyk: |
angličtina |
| Zdroj: |
RNA biology [RNA Biol] 2021 Oct 15; Vol. 18 (sup1), pp. 139-147. Date of Electronic Publication: 2021 Jul 25. |
| DOI: |
10.1080/15476286.2021.1952758 |
| Abstrakt: |
The ribonucleoprotein RNase MRP is responsible for the processing of ribosomal RNA precursors. It is found in virtually all eukaryotes that have been examined. In the Euglenozoa, including the genera Euglena, Diplonema and kinetoplastids, MRP RNA and protein subunits have so far escaped detection using bioinformatic methods. However, we now demonstrate that the RNA component is widespread among the Euglenozoa and that these RNAs have secondary structures that conform to the structure of all other phylogenetic groups. In Euglena, we identified the same set of P/MRP protein subunits as in many other protists. However, we failed to identify any of these proteins in the kinetoplastids. This finding poses interesting questions regarding the structure and function of RNase MRP in these species. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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