Impact of smoking on COVID-19 outcomes: a HOPE Registry subanalysis.

Autor:	Espejo-Paeres C; Cardiology, Hospital Clinico Universitario San Carlos Instituto Cardiovascular, Madrid, Spain., Núñez-Gil IJ; Cardiology/Internal Medicine, Hospital Clinico Universitario San Carlos Instituto Cardiovascular, Madrid, Spain., Estrada V; Cardiology/Internal Medicine, Hospital Clinico Universitario San Carlos Instituto Cardiovascular, Madrid, Spain., Fernández-Pérez C; Cardiology, University Hospital of Santiago de Compostela. Fundación IMAS, Galicia, Spain., Uribe-Heredia G; Cardiology, Hospital General Universitario de Guadalajara, Guadalajara, Spain., Cabré-Verdiell C; Cardiology, Hospital La Paz, Madrid, Spain., Uribarri A; Cardiology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain., Romero R; Cardiology/Emergency department, Hospital Universitario de Getafe, Madrid, Spain., García-Aguado M; Cardiology, Hospital Universitario Clinica Puerta de Hierro, Madrid, Spain., Fernández-Rozas I; Cardiology, Hospital Severo Ochoa, Madrid, Spain., Becerra-Muñoz V; Cardiology, Hospital Universitario Virgen de la Victoria; IBIMA. CIBERCV, Malaga, Spain., Pepe M; Cardiology, Policlinico di Bari Ospedale Giovanni XXIII, Bari, Italy., Cerrato E; Cardiology, Azienda Ospedaliero Universitaria San Luigi Gonzaga, Orbassano, Italy., Raposeiras-Roubín S; Cardiology, Hospital Alvaro Cunqueiro, Vigo, Spain., Barrionuevo-Ramos M; Cardiology, Hospital Infanta Sofia, Madrid, Spain., Aveiga-Ligua F; Cardiology, Hospital General del Norte de Guayaquil, Guayaquil, Ecuador., Aguilar-Andrea C; Emergency department, Hospital Universitario Principe de Asturias, Madrid, Spain., Alfonso-Rodríguez E; Cardiology, Instituto de Cardiología y Cirugía Cardiovascular, La Habana, Cuba., Ugo F; Cardiology, Sant'Andrea Hospital, Rome, Italy., García-Prieto JF; Cardiology, Hospital de Manises, Manises, Spain., Feltes G; Cardiology, Hospital Nuestra Señora de América, Madrid, Spain., Akin I; Cardiology, University Hospital Heidelberg, Heidelberg, Germany., Huang J; The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, China., Jativa J; Cardiology, Hospital de Especialidades Fuerzas Armadas N 1, Quito, Ecuador., Fernández-Ortiz A; Cardiology/Internal Medicine, Hospital Clinico Universitario San Carlos Instituto Cardiovascular, Madrid, Spain., Macaya C; Cardiology/Internal Medicine, Hospital Clinico Universitario San Carlos Instituto Cardiovascular, Madrid, Spain., Carrero-Fernández A; Emergency department, Hospital Universitario Principe de Asturias, Madrid, Spain., Signes-Costa J; Pneumology, Hospital Clínico Universitario, Incliva. Universidad de Valencia, Valencia, Spain.
Jazyk:	angličtina
Zdroj:	BMJ nutrition, prevention & health [BMJ Nutr Prev Health] 2021 Jun 17; Vol. 4 (1), pp. 285-292. Date of Electronic Publication: 2021 Jun 17 (Print Publication: 2021).
DOI:	10.1136/bmjnph-2021-000269
Abstrakt:	Background: Smoking has been associated with poorer outcomes in relation to COVID-19. Smokers have higher risk of mortality and have a more severe clinical course. There is paucity of data available on this issue, and a definitive link between smoking and COVID-19 prognosis has yet to be established. Methods: We included 5224 patients with COVID-19 with an available smoking history in a multicentre international registry Health Outcome Predictive Evaluation for COVID-19 (NCT04334291). Patients were included following an in-hospital admission with a COVID-19 diagnosis. We analysed the outcomes of patients with a current or prior history of smoking compared with the non-smoking group. The primary endpoint was all-cause in-hospital death. Results: Finally, 5224 patients with COVID-19 with available smoking status were analysed. A total of 3983 (67.9%) patients were non-smokers, 934 (15.9%) were former smokers and 307 (5.2%) were active smokers. The median age was 66 years (IQR 52.0-77.0) and 58.6% were male. The most frequent comorbidities were hypertension (48.5%) and dyslipidaemia (33.0%). A relevant lung disease was present in 19.4%. In-hospital complications such sepsis (23.6%) and embolic events (4.3%) occurred more frequently in the smoker group (p<0.001 for both). All cause-death was higher among smokers (active or former smokers) compared with non-smokers (27.6 vs 18.4%, p<0.001). Following a multivariate analysis, current smoking was considered as an independent predictor of mortality (OR 1.77, 95% CI 1.11 to 2.82, p=0.017) and a combined endpoint of severe disease (OR 1.68, 95% CI 1.16 to 2.43, p=0.006). Conclusion: Smoking has a negative prognostic impact on patients hospitalised with COVID-19. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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