Neonatal acute liver failure with pulmonary yellow hyaline membrane and kernicterus.
| Autor: | Oh KS; Mount Sinai Medical Center, Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Miami, FL, USA., Bahmad HF; Mount Sinai Medical Center, Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Miami, FL, USA., Brathwaite C; Nicklaus Children's Hospital, Miami, FL, USA., Sanchez AC; Mount Sinai Medical Center, Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Miami, FL, USA.; Florida International University, Herbert Wertheim College of Medicine, Miami, FL, USA., Recine M; Mount Sinai Medical Center, Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Miami, FL, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Autopsy & case reports [Autops Case Rep] 2021 May 06; Vol. 11, pp. e2021268. Date of Electronic Publication: 2021 May 06 (Print Publication: 2021). |
| DOI: | 10.4322/acr.2021.268 |
| Abstrakt: | Background: Neonatal acute liver failure (NALF) is a rare and life-threatening condition. It causes bilirubin to accumulate to a dangerous level in the body, causing permanent damage to vital organs such as the brain and lungs. In many cases, the etiology of NALF remains unknown. Case Presentation: We described a case of an 8-day-old baby girl who presented with poor oral intake, lethargy, and jaundice. Her clinical condition rapidly deteriorated with progression to multi-organ failure, and despite intensive resuscitation efforts, she expired. At autopsy, the most significant findings were liver necrosis, yellow hyaline membrane deposition in the lungs, and bilirubin deposition in the brain (kernicterus). Conclusions: NALF is a rare and potentially fatal condition necessitating prompt recognition and disease-specific treatment approaches. Toxic accumulation of bilirubin in the lungs can lead to hypoxia and precipitate further ischemic injury to the liver. Competing Interests: Conflict of interest: The authors declare that the study was conducted in the absence of any commercial or financial relationships that could be construed as a potential. (Copyright © 2021 The Authors.) |
| Databáze: | MEDLINE |
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