Post-traumatic Neuroinflammation: Relevance to Pediatrics.

Autor: Ashwal S; Department of Pediatrics, Loma Linda University, School of Medicine, Loma Linda, California. Electronic address: sashwal@llu.edu., Siebold L; Department of Pediatrics, Loma Linda University, School of Medicine, Loma Linda, California., Krueger AC; Department of Pediatrics, Loma Linda University, School of Medicine, Loma Linda, California., Wilson CG; Department of Pediatrics, Loma Linda University, School of Medicine, Loma Linda, California.
Jazyk: angličtina
Zdroj: Pediatric neurology [Pediatr Neurol] 2021 Sep; Vol. 122, pp. 50-58. Date of Electronic Publication: 2021 Apr 27.
DOI: 10.1016/j.pediatrneurol.2021.04.010
Abstrakt: Both detrimental and beneficial effects of post-traumatic neuroinflammation have become a major research focus as they offer the potential for immediate as well as delayed targeted reparative therapies. Understanding the complex interactions of central and peripheral immunocompetent cells as well as their mediators on brain injury and recovery is complicated by the temporal, regional, and developmental differences in their response to injuries. Microglia, the brain-resident macrophages, have become central in these investigations as they serve a major surveillance function, have the ability to react swiftly to injury, recruit various cellular and chemical mediators, and monitor the reparative/degenerative processes. In this review we describe selected aspects of this burgeoning literature, describing the critical role of cytokines and chemokines, microglia, advances in neuroimaging, genetics and fractal morphology analysis, our research efforts in this area, and selected aspects of pediatric post-traumatic neuroinflammation.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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