The Rapidly-Developing Area of Radiocardiology: Principles, Complications and Applications of Radiotherapy on the Heart.

Autor: Aguilar M; Department of Medicine and Research Center, Montréal Heart Institute and Université de Montréal, Montréal, Québec, Canada. Electronic address: martin.aguilar@umontreal.ca., Qian PC; Westmead Applied Research Center, Westmead Hospital, Sydney, Australia; Westmead Institute for Medical Research, Westmead Hospital, Sydney, Australia; University of Sydney, Sydney, Australia., Boeck M; Harvard Medical School, Boston, Massachusetts, USA; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts, USA., Bredfeldt J; Harvard Medical School, Boston, Massachusetts, USA; Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, Massachusetts, USA., Seuntjens J; Medical Physics Unit, McGill University Health Center, Montréal, Québec, Canada., Hijal T; Medical Physics Unit, McGill University Health Center, Montréal, Québec, Canada., Bernier ML; Division of Cardiology, McGill University Health Center, Montréal, Québec, Canada., Zei P; Department of Medicine and Research Center, Montréal Heart Institute and Université de Montréal, Montréal, Québec, Canada; Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Jazyk: angličtina
Zdroj: The Canadian journal of cardiology [Can J Cardiol] 2021 Nov; Vol. 37 (11), pp. 1818-1827. Date of Electronic Publication: 2021 Jul 22.
DOI: 10.1016/j.cjca.2021.07.011
Abstrakt: Ventricular arrhythmias are the leading cause of sudden cardiac death. Current treatment strategies for ventricular tachycardia, including antiarrhythmic drugs and catheter ablation, have limited efficacy in patients with structural heart disease. Noninvasive ablation with the use of externally applied radiation (cardiac radioablation) has emerged as a promising and novel approach to treating recurrent ventricular tachycardias. However, the heart is generally an "organ at risk" for radiation treatments, such that very little is known on the effects of radiotherapy on cardiac ultrastructure and electrophysiologic properties. Furthermore, there has been limited interaction between the fields of cardiology and radiation oncology and physics. The advent of cardiac radioablation will undoubtedly increase interactions between cardiologists, cardiac electrophysiologists, radiation oncologists and physicists. There is an important knowledge gap separating these specialties, but scientific developments, technical optimisation, and improvements depend on intense multidisciplinary collaboration. This manuscript seeks to review the basic of radiation physics and biology for cardiovascular specialists in an effort to facilitate constructive scientific and clinical collaborations to improve patient outcomes.
(Copyright © 2021 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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