Hydrogen Sulfide: a Novel Immunoinflammatory Regulator in Rheumatoid Arthritis.

Autor: Li M; State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China., Mao JC; Department of Rheumatology, Longhua Hospital, Shanghai University of Chinese Medicine, Shanghai, China., Zhu YZ; State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. yzzhu@must.edu.mo.; School of Pharmacy, Macau University of Science and Technology, Avenida Wai Long, Taipa, Macau, China. yzzhu@must.edu.mo.; Shanghai Key Laboratory of Bioactive Small Molecules, Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China. yzzhu@must.edu.mo.
Jazyk: angličtina
Zdroj: Advances in experimental medicine and biology [Adv Exp Med Biol] 2021; Vol. 1315, pp. 161-179.
DOI: 10.1007/978-981-16-0991-6_7
Abstrakt: Hydrogen sulfide (H 2 S), an endogenous, gaseous, signaling transmitter, has been shown to have vasodilative, anti-oxidative, anti-inflammatory, and cytoprotective activities. Increasing evidence also indicates that H 2 S can suppress the production of inflammatory mediators by immune cells, for example, T cells and macrophages. Inflammation is closely related to an immune response in several diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE), and cancer. Considering these biological effects of H 2 S, a potential role in the treatment of immune-related RA is being exploited. In the present review, we will provide an overview of the therapeutic potential of H 2 S in RA treatment.
(© 2021. Springer Nature Singapore Pte Ltd.)
Databáze: MEDLINE
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