Development of whole-body representation and dose calculation in a commercial treatment planning system.

Autor: Hauri P; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland., Radonic S; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland., Vasi F; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland., Ernst M; Department of Physics, University of Zurich, Zurich, Switzerland., Sumila M; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland., Mille MM; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA., Lee C; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA., Hartmann M; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland., Schneider U; Department of Physics, University of Zurich, Zurich, Switzerland; Radiotherapy Hirslanden, Hirslanden Medical Center, Aarau, Switzerland.
Jazyk: angličtina
Zdroj: Zeitschrift fur medizinische Physik [Z Med Phys] 2022 May; Vol. 32 (2), pp. 159-172. Date of Electronic Publication: 2021 Jul 21.
DOI: 10.1016/j.zemedi.2021.05.001
Abstrakt: For the epidemiological evaluation of long-term side effects of radiotherapy patients, it is important to know the doses to organs and tissues everywhere in the patient. Computed tomography (CT) images of the patients which contain the anatomical information are sometimes available for each treated patient. However, the available CT scans usually cover only the treated volume of the patient including the target and surrounding anatomy. To overcome this limitation, in this work we describe the development of a software tool using the Varian Eclipse Scripting API for extending a partial-body CT to a whole-body representation in the treatment planning system for dose calculation. The whole-body representation is created by fusing the partial-body CT with a similarly sized whole-body computational phantom selected from a library containing 64 phantoms of different heights, weights, and genders. The out-of-field dose is calculated with analytical models from the literature and merged with the treatment planning system-calculated dose. To test the method, the out-of-field dose distributions on the computational phantoms were compared to dose calculations on whole-body patient CTs. The mean doses, D2% and D98% were compared in 26 organs and tissues for 14 different treatment plans in 5 patients using 3D-CRT, IMRT, VMAT, coplanar and non-coplanar techniques. From these comparisons we found that mean relative differences between organ doses ranged from -10% and +20% with standard deviations of up to 40%. The developed method will help epidemiologists and researchers estimate organ doses outside the treated volume when only limited treatment planning CT information is available.
(Copyright © 2021. Published by Elsevier GmbH.)
Databáze: MEDLINE
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