Multibiomarker responses and bioaccumulation of fipronil in Prochilodus lineatus exposed to spiked sediments: Oxidative stress and antioxidant defenses.

Autor: Santillán Deiú A; Grupo de Estudios de Contaminación Antrópica de Peces (GECAP), Departamento de Ciencias Básicas e INEDES, Universidad Nacional de Luján (UNLu-CONICET), Rutas 5 y 7, Luján 6700, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina., Ondarza PM; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; Laboratorio de Ecotoxicología y Contaminación Ambiental, Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET), Universidad Nacional de Mar del Plata, D Funes 3350, Mar del Plata 7600, Argentina., Miglioranza KSB; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina; Laboratorio de Ecotoxicología y Contaminación Ambiental, Instituto de Investigaciones Marinas y Costeras (IIMyC-CONICET), Universidad Nacional de Mar del Plata, D Funes 3350, Mar del Plata 7600, Argentina., de la Torre FR; Grupo de Estudios de Contaminación Antrópica de Peces (GECAP), Departamento de Ciencias Básicas e INEDES, Universidad Nacional de Luján (UNLu-CONICET), Rutas 5 y 7, Luján 6700, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. Electronic address: fdelatorre@unlu.edu.ar.
Jazyk: angličtina
Zdroj: Pesticide biochemistry and physiology [Pestic Biochem Physiol] 2021 Aug; Vol. 177, pp. 104876. Date of Electronic Publication: 2021 May 21.
DOI: 10.1016/j.pestbp.2021.104876
Abstrakt: Fipronil is a current use pesticide, widely used in many crops, commonly adsorbed to sediments of aquatic environments. The purpose of this study was to evaluate the biomarker responses and fipronil distribution pattern in different matrixes (fish, sediment and water) after juveniles P. lineatus exposure at two environmental concentrations (5.5 and 82 μg kg - -1 ) of fipronil-spiked sediments. The levels of oxidized proteins (PO), lipid peroxidation (LPO), and enzymatic activity of superoxide dismutase (SOD), reduced glutathione content (GSH), antioxidant capacity against peroxyls (ACAP) and acetylcholinesterase (AChE) were evaluated in liver, gills and brain. Concentrations of fipronil and its metabolites (f. desulfinyl, f sulphpHide and f. sulfone) were quantified by GC-ECD. F. desulfinyl was the major metabolite found in all matrixes, followed by f. sulphide in sediments, while f. sulfone was mainly accumulated in fish. Fipronil promoted oxidative stress in P. lineatus, as evidenced by the increases in LPO and PO levels and the decrease brain AChE activity. Fish exposed at both concentrations showed significant decrease in antioxidant capacity. Alterations in the antioxidant defenses system was evidenced in all organs. These results suggest that the occurrence of fipronil in aquatic environments can generate oxidative stress at different levels in P. lineatus, showing that this species is highly sensitive to the deleterious effects of fipronil and metabolites.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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