Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

Autor: Khor BH; Faculty of Medicine, Department of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.; Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia., Tiong HC; Faculty of Medicine, Department of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Tan SC; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Wong SK; Faculty of Medicine, Department of Pharmacology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Chin KY; Faculty of Medicine, Department of Pharmacology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Karupaiah T; Faculty of Health and Medical Sciences, School of Biosciences, Taylor's University, Subang Jaya, Selangor, Malaysia., Ima-Nirwana S; Faculty of Medicine, Department of Pharmacology, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia., Abdul Gafor AH; Faculty of Medicine, Department of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Jul 23; Vol. 16 (7), pp. e0255205. Date of Electronic Publication: 2021 Jul 23 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0255205
Abstrakt: Studies investigating the effects of tocotrienols on inflammation and oxidative stress have yielded inconsistent results. This systematic review and meta-analysis aimed to evaluate the effects of tocotrienols supplementation on inflammatory and oxidative stress biomarkers. We searched PubMed, Scopus, and Cochrane Central Register of Controlled Trials from inception until 13 July 2020 to identify randomized controlled trials supplementing tocotrienols and reporting circulating inflammatory or oxidative stress outcomes. Weighted mean difference (WMD) and corresponding 95% confidence interval (CI) were determined by pooling eligible studies. Nineteen studies were included for qualitative analysis, and 13 studies were included for the meta-analyses. A significant reduction in C-reactive protein levels (WMD: -0.52 mg/L, 95% CI: -0.73, -0.32, p < 0.001) following tocotrienols supplementation was observed, but this finding was attributed to a single study using δ-tocotrienols, not mixed tocotrienols. There were no effects on interleukin-6 (WMD: 0.03 pg/mL, 95% CI: -1.51, 1.58, p = 0.966), tumor necrosis factor-alpha (WMD: -0.28 pg/mL, 95% CI: -1.24, 0.68, p = 0.571), and malondialdehyde (WMD: -0.42 μmol/L, 95% CI: -1.05, 0.21, p = 0.189). A subgroup analysis suggested that tocotrienols at 400 mg/day might reduce malondialdehyde levels (WMD: -0.90 μmol/L, 95% CI: -1.20, -0.59, p < 0.001). Future well-designed studies are warranted to confirm the effects of tocotrienols on inflammatory and oxidative stress biomarkers, particularly on different types and dosages of supplementation. PROSPERO registration number: CRD42020198241.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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