Near-Infrared Light Increases Functional Connectivity with a Non-thermal Mechanism.

Autor: Dmochowski GM; Princess Margaret Cancer Centre, Toronto, ON M5G 1L7, Canada., Shereen AD; Advanced Science Research Center, Graduate Center of the City University of New York, New York, NY 10031, USA., Berisha D; Department of Biomedical Engineering, City College of New York, New York, NY 10031, USA., Dmochowski JP; Department of Biomedical Engineering, City College of New York, New York, NY 10031, USA.
Jazyk: angličtina
Zdroj: Cerebral cortex communications [Cereb Cortex Commun] 2020 Mar 19; Vol. 1 (1), pp. tgaa004. Date of Electronic Publication: 2020 Mar 19 (Print Publication: 2020).
DOI: 10.1093/texcom/tgaa004
Abstrakt: Although techniques for noninvasive brain stimulation are under intense investigation, an approach that has received limited attention is transcranial photobiomodulation (tPBM), the delivery of near-infrared light to the brain with a laser or light-emitting diode directed at the scalp. Here we employed functional magnetic resonance imaging to measure the blood-oxygenation-level-dependent signal in n  = 20 healthy human participants while concurrently stimulating their right frontal pole with a near-infrared laser. Functional connectivity with the illuminated region increased by up to 15% during stimulation, with a quarter of all connections experiencing a significant increase. The time course of connectivity exhibited a sharp rise approximately 1 min after illumination onset. Brain-wide connectivity increases were also observed, with connections involving the stimulated hemisphere showing a significantly larger increase than those in the contralateral hemisphere. We subsequently employed magnetic resonance thermometry to measure brain temperature during tPBM (separate cohort, n  = 20) and found no significant temperature differences between active and sham stimulation. Our findings suggest that near-infrared light synchronizes brain activity with a nonthermal mechanism, underscoring the promise of tPBM as a new technique for stimulating brain function.
(© The Author(s) 2020. Published by Oxford University Press.)
Databáze: MEDLINE
Externí odkaz: