Links between fecal microbiota and the response to vaccination against influenza A virus in pigs.

Autor:	Borey M; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France. marion.borey@inrae.fr., Blanc F; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Lemonnier G; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Leplat JJ; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Jardet D; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Rossignol MN; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Ravon L; INRAE, GenESI, Surgères, France., Billon Y; INRAE, GenESI, Surgères, France., Bernard M; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Estellé J; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France., Rogel-Gaillard C; Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France. claire.rogel-gaillard@inrae.fr.
Jazyk:	angličtina
Zdroj:	NPJ vaccines [NPJ Vaccines] 2021 Jul 22; Vol. 6 (1), pp. 92. Date of Electronic Publication: 2021 Jul 22.
DOI:	10.1038/s41541-021-00351-2
Abstrakt:	This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum levels of IAV-specific IgG and assays of hemagglutination inhibition (HAI). Analysis of the pre-vaccination microbiota characterized by 16S rRNA gene sequencing of fecal DNA reveals a higher vaccine response in piglets with a richer microbiota, and shows that 23 operational taxonomic units (OTUs) are differentially abundant between high and low IAV-specific IgG producers at D63. A stronger immune response is linked with OTUs assigned to the genus Prevotella and family Muribaculaceae, and a weaker response is linked with OTUs assigned to the genera Helicobacter and Escherichia-Shigella. A set of 81 OTUs accurately predicts IAV-specific IgG and HAI titer levels at all time points, highlighting early and late associations between pre-vaccination fecal microbiota composition and immune response to the vaccine. (© 2021. The Author(s).)
Databáze:	MEDLINE
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