Identification of chronic thromboembolic pulmonary hypertension on CTPAs performed for diagnosing acute pulmonary embolism depending on level of expertise.

Autor: Boon GJAM; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: g.j.a.m.boon@LUMC.nl., Jairam PM; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Groot GMC; Department of Radiology, Medical Center Gelderse Vallei, Ede, the Netherlands., van Rooden CJ; Department of Radiology, Haga Teaching Hospital, Den Haag, the Netherlands., Ende-Verhaar YM; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Beenen LFM; Department of Radiology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands., Kroft LJM; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Bogaard HJ; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands., Huisman MV; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands., Symersky P; Department of Cardiothoracic Surgery, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands., Vonk Noordegraaf A; Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University Medical Center, Amsterdam, the Netherlands., Meijboom LJ; Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands., Klok FA; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Jazyk: angličtina
Zdroj: European journal of internal medicine [Eur J Intern Med] 2021 Nov; Vol. 93, pp. 64-70. Date of Electronic Publication: 2021 Jul 20.
DOI: 10.1016/j.ejim.2021.07.001
Abstrakt: Background: Expert reading often reveals radiological signs of chronic thromboembolic pulmonary hypertension (CTEPH) or chronic PE on computed tomography pulmonary angiography (CTPA) performed at the time of acute pulmonary embolism (PE) presentation preceding CTEPH. Little is known about the accuracy and reproducibility of CTPA reading by radiologists in training in this setting.
Objectives: To evaluate 1) whether signs of CTEPH or chronic PE are routinely reported on CTPA for suspected PE; and 2) whether CTEPH-non-expert readers achieve comparable predictive accuracy to CTEPH-expert radiologists after dedicated instruction.
Methods: Original reports of CTPAs demonstrating acute PE in 50 patients whom ultimately developed CTEPH, and those of 50 PE who did not, were screened for documented signs of CTEPH. All scans were re-assessed by three CTEPH-expert readers and two CTEPH-non-expert readers (blinded and independently) for predefined signs and overall presence of CTEPH.
Results: Signs of chronic PE were mentioned in the original reports of 14/50 cases (28%), while CTEPH-expert radiologists had recognized 44/50 (88%). Using a standardized definition (≥3 predefined radiological signs), moderate-to-good agreement was reached between CTEPH-non-expert readers and the experts' consensus (k-statistics 0.46; 0.61) at slightly lower sensitivities. The CTEPH-non-expert readers had moderate agreement on the presence of CTEPH (κ-statistic 0.38), but both correctly identified most cases (80% and 88%, respectively).
Conclusions: Concomitant signs of CTEPH were poorly documented in daily practice, while most CTEPH patients were identified by CTEPH-non-expert readers after dedicated instruction. These findings underline the feasibility of achieving earlier CTEPH diagnosis by assessing CTPAs more attentively.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: