Chemical modification strategies for viscosity-dependent processing of gellan gum.

Autor: Gering C; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland. Electronic address: christine.gering@tuni.fi., Rasheed A; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland., Koivisto JT; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland; Division of Pathology, Department of Laboratory Medicine, Karolinska Institute, 171 77 Stockholm, Sweden., Párraga J; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland., Tuukkanen S; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland., Kellomäki M; Faculty of Medicine and Health Technology, Tampere University, 33720 Tampere, Finland.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2021 Oct 01; Vol. 269, pp. 118335. Date of Electronic Publication: 2021 Jun 15.
DOI: 10.1016/j.carbpol.2021.118335
Abstrakt: Recently, the hydrogel-forming polysaccharide gellan gum (GG) has gained popularity as a versatile biomaterial for tissue engineering purposes. Here, we examine the modification strategies suitable for GG to overcome processing-related limitations. We emphasize the thorough assessment of the viscoelastic and mechanical properties of both precursor solutions and final hydrogels. The investigated modification strategies include purification, oxidation, reductive chain scission, and blending. We correlate polymer flow and hydrogel forming capabilities to viscosity-dependent methods including casting, injection and printing. Native GG and purified NaGG are shear thinning and feasible for printing, being similar in gelation and compression behavior. Oxidized GGox possesses reduced viscosity, higher toughness, and aldehydes as functional groups, while scissored GGsciss has markedly lower molecular weight. To exemplify extrudability, select modification products are printed using an extrusion-based bioprinter utilizing a crosslinker bath. Our robust modification strategies have widened the processing capabilities of GG without affecting its ability to form hydrogels.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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