The Outcomes of Laparoscopic Biliopancreatic Diversion with Duodenal Switch on Gastro-esophageal Reflux Disease: the Mayo Clinic Experience.

Autor: Badaoui JN; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Kellogg TA; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Abu Dayyeh BK; Department of Medicine, Mayo Clinic, Rochester, MN, USA., Maroun JW; Department of Surgery, Mayo Clinic, Rochester, MN, USA., McKenzie TJ; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Harmsen WS; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Kendrick ML; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Ghanem OM; Department of Surgery, Mayo Clinic, Rochester, MN, USA. Ghanem.Omar@mayo.edu.; Division of Endocrine & Metabolic Surgery, Mayo Clinic College of Medicine, Mayo Clinic, 200 1st Street SW, Rochester, MN, 55905, USA. Ghanem.Omar@mayo.edu.
Jazyk: angličtina
Zdroj: Obesity surgery [Obes Surg] 2021 Oct; Vol. 31 (10), pp. 4363-4370. Date of Electronic Publication: 2021 Jul 22.
DOI: 10.1007/s11695-021-05581-w
Abstrakt: Purpose: The outcomes of laparoscopic biliopancreatic diversion with duodenal switch (BPD-DS) on gastro-esophageal reflux disease (GERD) are not well elucidated.
Material/methods: This retrospective review included patients undergoing laparoscopic primary BPD-DS at Mayo Clinic from 2009 to 2019. GERD parameters analyzed included subjective symptom report/anti-reflux medication intake and/or endoscopic findings. GERD-HRQL questionnaire was also utilized post-operatively. Three subgroups were employed to stratify patients depending on GERD outcomes: the "No-effect" subgroup included patients where surgery did not affect either positively (GERD resolution) or negatively (de novo GERD) GERD outcome, "De novo GERD" subgroup, and "GERD-resolved" subgroup. Multinomial logistic modeling was used to examine associations with the 3-level GERD subgroup (p<0.05).
Results: Seventy-six patients were included in the analysis. Thirty-four (44.7%) patients were found to be in the "GERD-resolved" subgroup, 28 (36.8%) patients in the "No-effect" subgroup, and 14 (18.4%) patients in the "De novo GERD" subgroup. Multinomial logistic modeling showed that patients with pre-surgery diabetes mellitus (DM) had lesser odds (OR= 0.248, (95% CI: 0.085-0.724, p=0.0108)) of GERD resolution than patients without pre-surgery DM. An association was also established between %TWL at 6 and 12 months following the procedure and GERD outcome (p=0.017 and 0.008, respectively). Finally, the mean (SD) post-operative GERD-HRQL score was 8.7 (8.1) points, and 69 (91%) patients were currently satisfied with their post-operative condition.
Conclusion: Laparoscopic BPD-DS appears to have a satisfactory GERD outcome in most patients undergoing the operation. There appears to be an association between pre-operative DM, %TWL at 6 and 12 months, and GERD prognosis in this population.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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