Asthma in Youth and Early-onset Type 2 Diabetes: A Nationwide Study of 1.72 Million Israeli Adolescents.

Autor:	Shapiro M; Department of Internal Medicine T, Tel Aviv Sourasky Medical Center, Tel Aviv 6492601, Israel.; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel., Arbel C; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Zucker I; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan 5262160, Israel., Balmor GR; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel., Lutski M; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; The Israel Center for Disease Control, Ministry of Health, Ramat Gan 5262160, Israel., Derazne E; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel., Beer Z; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Pinhas-Hamiel O; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Department of Pediatric Endocrinology, Safra Children Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Mosenzon O; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel., Tzur D; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel., Afek A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Central Management, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Tirosh A; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Cukierman-Yaffe T; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario L8S 4M1, Canada., Rosenberg V; Maccabitech Research Institute, Maccabi Healthcare Services, Tel Aviv 6801296, Israel., Chodick G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Maccabitech Research Institute, Maccabi Healthcare Services, Tel Aviv 6801296, Israel., Raz I; The Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem 91120, Israel., Twig G; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.; Israel Defense Forces Medical Corps, Ramat Gan 5510802, Israel.; Department of Military Medicine, Hebrew University of Jerusalem, Faculty of Medicine, Jerusalem 9112102, Israel.; Institute of Endocrinology, Sheba Medical Center, Tel Hashomer, Ramat Gan 5266202, Israel.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2021 Nov 19; Vol. 106 (12), pp. e5043-e5053.
DOI:	10.1210/clinem/dgab542
Abstrakt:	Background: The prevalence of both asthma and early-onset diabetes is on the rise; however, the association between them remains unclear. We examined a possible association of asthma at adolescence with type 2 diabetes in young adulthood. Methods: This is a nationwide, population-based study of 1 718 541 Israeli adolescents (57% males; mean age 17.3 years; range 16-19 years), examined before compulsory military service between 1992 and 2016, with data linked to the Israeli National Diabetes Registry. Asthma diagnosis and severity were determined by a board-certified pulmonologist and based on spirometry tests. Results: Type 2 diabetes developed in 58/9090 (0.64%), 507/97 059 (0.52%), 114/23 332 (0.49%), and 7095/1 589 060 (0.44%) persons with moderate-to-severe, mild, inactive, and no history of asthma, respectively, during a mean follow-up >13 years. The respective odds ratios (ORs) were 1.33 (95% CI, 1.02-1.74), 1.17 (1.06-1.28), and 1.09 (0.9-1.31), considering those without asthma history as the reference, in a model adjusted for birth year, sex, body mass index, and other sociodemographic variables. The association persisted when the analysis accounted for coexisting morbidities, and when persons without asthma, individually matched by age, sex, birth year, and body mass index were the reference. Both mild and moderate-to-severe asthma were associated with type 2 diabetes before age 35 years: ORs 1.18 (1.05-1.34) and 1.44 (1.05-2.00), respectively. The strength of the association was accentuated over time. The effect was unchanged when adjusted for oral and inhaled glucocorticoid use. Conclusion: Adolescents with active asthma have higher risk to develop type 2 diabetes. This seems related to disease severity, independent of adolescent obesity status, apparent before age 35 years, and more pronounced in recent years. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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